TY - JOUR
T1 - Differential agglutination by soybean agglutinin of human leukemia and neuroblastoma cell lines
T2 - Potential application to autologous bone marrow transplantation
AU - Reisner, Y.
PY - 1983
Y1 - 1983
N2 - Normal human bone marrow cells were mixed with radioactively labeled tumor cells from different leukemia and neuroblastoma cell lines, and the cell mixtures were separated by differential agglutination with soybean agglutinin. It is shown that the cell fraction unagglutinated by soybean agglutinin, which was previously found to be capable of reconstituting the hematopoietic system of lethally tradiated recipients, can be purged of tumor cells with varying efficiency depending on the tumor cell expression of soybean agglutinin receptors as detected by flow cytofluorimetry with fluoresceinated soybean agglutinin.
AB - Normal human bone marrow cells were mixed with radioactively labeled tumor cells from different leukemia and neuroblastoma cell lines, and the cell mixtures were separated by differential agglutination with soybean agglutinin. It is shown that the cell fraction unagglutinated by soybean agglutinin, which was previously found to be capable of reconstituting the hematopoietic system of lethally tradiated recipients, can be purged of tumor cells with varying efficiency depending on the tumor cell expression of soybean agglutinin receptors as detected by flow cytofluorimetry with fluoresceinated soybean agglutinin.
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U2 - 10.1073/pnas.80.21.6657
DO - 10.1073/pnas.80.21.6657
M3 - Article
C2 - 6356131
AN - SCOPUS:0021085434
SN - 0027-8424
VL - 80
SP - 6657
EP - 6661
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 21 I
ER -