Differential Diagnosis of Diarrhea in Patients with Neuroendocrine Tumors

Jennifer R. Eads; Diane Reidy-Lagunes; Heloisa P. Soares; Jennifer A. Chan; Lowell B. Anthony; Thorvardur R. Halfdanarson; Boris G. Naraev; Edward M. Wolin; Daniel M. Halperin; Daneng Li; Rodney F. Pommier; Jerome S. Zacks; Michael A. Morse; David C. Metz

doi:10.1097/MPA.0000000000001658

Differential Diagnosis of Diarrhea in Patients with Neuroendocrine Tumors

Jennifer R. Eads, Diane Reidy-Lagunes, Heloisa P. Soares, Jennifer A. Chan, Lowell B. Anthony, Thorvardur R. Halfdanarson, Boris G. Naraev, Edward M. Wolin, Daniel M. Halperin, Daneng Li, Rodney F. Pommier, Jerome S. Zacks, Michael A. Morse, David C. Metz

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.

Original language	English (US)
Pages (from-to)	1123-1130
Number of pages	8
Journal	Pancreas
Volume	49
Issue number	9
DOIs	https://doi.org/10.1097/MPA.0000000000001658
State	Published - Oct 2020
Externally published	Yes

Keywords

carcinoid syndrome
diagnostic algorithm
neuroendocrine tumor
osmolar gap
secretory diarrhea

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

Access to Document

10.1097/MPA.0000000000001658

Cite this

@article{e36e075c604340bf904f97ff21d4776a,

title = "Differential Diagnosis of Diarrhea in Patients with Neuroendocrine Tumors",

abstract = "Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.",

keywords = "carcinoid syndrome, diagnostic algorithm, neuroendocrine tumor, osmolar gap, secretory diarrhea",

author = "Eads, {Jennifer R.} and Diane Reidy-Lagunes and Soares, {Heloisa P.} and Chan, {Jennifer A.} and Anthony, {Lowell B.} and Halfdanarson, {Thorvardur R.} and Naraev, {Boris G.} and Wolin, {Edward M.} and Halperin, {Daniel M.} and Daneng Li and Pommier, {Rodney F.} and Zacks, {Jerome S.} and Morse, {Michael A.} and Metz, {David C.}",

year = "2020",

month = oct,

doi = "10.1097/MPA.0000000000001658",

language = "English (US)",

volume = "49",

pages = "1123--1130",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Differential Diagnosis of Diarrhea in Patients with Neuroendocrine Tumors

AU - Eads, Jennifer R.

AU - Reidy-Lagunes, Diane

AU - Soares, Heloisa P.

AU - Chan, Jennifer A.

AU - Anthony, Lowell B.

AU - Halfdanarson, Thorvardur R.

AU - Naraev, Boris G.

AU - Wolin, Edward M.

AU - Halperin, Daniel M.

AU - Li, Daneng

AU - Pommier, Rodney F.

AU - Zacks, Jerome S.

AU - Morse, Michael A.

AU - Metz, David C.

PY - 2020/10

Y1 - 2020/10

N2 - Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.

AB - Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.

KW - carcinoid syndrome

KW - diagnostic algorithm

KW - neuroendocrine tumor

KW - osmolar gap

KW - secretory diarrhea

UR - http://www.scopus.com/inward/record.url?scp=85092681910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85092681910&partnerID=8YFLogxK

U2 - 10.1097/MPA.0000000000001658

DO - 10.1097/MPA.0000000000001658

M3 - Review article

C2 - 32991344

AN - SCOPUS:85092681910

SN - 0885-3177

VL - 49

SP - 1123

EP - 1130

JO - Pancreas

JF - Pancreas

IS - 9

ER -

Differential Diagnosis of Diarrhea in Patients with Neuroendocrine Tumors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this