Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI

Leila R. Lindeman; Kyle M. Jones; Rachel A. High; Christine M. Howison; Lisa F. Shubitz; Mark D. Pagel

doi:10.1038/s41598-019-49514-1

Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI

Leila R. Lindeman, Kyle M. Jones, Rachel A. High, Christine M. Howison, Lisa F. Shubitz, Mark D. Pagel

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

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Abstract

Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.

Original language	English (US)
Article number	13002
Journal	Scientific reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-49514-1
State	Published - Dec 1 2019

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title = "Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI",

abstract = "Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.",

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AU - Pagel, Mark D.

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AB - Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.

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Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI

Abstract

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