TY - JOUR
T1 - Diffusion Tensor Imaging Indicators of White Matter Injury Are Correlated with a Multimodal Electroencephalography-Based Biomarker in Slow Recovering, Concussed Collegiate Athletes
AU - Wilde, Elisabeth A.
AU - Goodrich-Hunsaker, Naomi J.
AU - Ware, Ashley L.
AU - Taylor, Brian A.
AU - Biekman, Brian D.
AU - Hunter, Jill V.
AU - Newman-Norlund, Roger
AU - Scarneo, Samantha
AU - Casa, Douglas J.
AU - Levin, Harvey S.
N1 - Funding Information:
The clinical study was funded, in part, by a contract to Brain-Scope Company Inc. from the U.S. Navy (Naval Health Research Center), contract #W911QY-14-C-0098.
Publisher Copyright:
© 2020, Mary Ann Liebert, Inc., publishers.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - There are no validated, objective diagnostic or prognostic biomarkers for sports-related concussion (SRC), which hinders evidence-based treatment for concussed athletes. While quantitative electrophysiology (EEG) and diffusion tensor imaging (DTI) are promising technologies for providing objective biomarkers for concussion, the degree to which they are related has not been systematically investigated in concussed athletes. This study examined whether diffusion metrics differentiated concussed athletes with prolonged recovery (n = 18) from non-conccused athletes (n = 13) and whether observed diffusion alterations related to EEG. Collegiate athletes (N = 31) completed EEG, neurocognitive, and magnetic resonance imaging. White matter diffusivity differed between the groups in multiple white matter tracts, including the corpus callosum, cingulum bundle, thalamic radiations, and inferior fronto-occipital, inferior longitudinal, and uncinate fasciculi, but not after correction for multiple comparisons. The enhanced Brain Function Index (eBFI), a measure that combines EEG and neurocognitive data, significantly correlated with altered diffusion in the concussed athletes. These preliminary findings suggest that the absolute deviation of diffusion metrics in concussed versus non-concussed athletes may have clinically utility. Results also suggested that the eBFI may be sensitive to early changes from sports-related concussion.
AB - There are no validated, objective diagnostic or prognostic biomarkers for sports-related concussion (SRC), which hinders evidence-based treatment for concussed athletes. While quantitative electrophysiology (EEG) and diffusion tensor imaging (DTI) are promising technologies for providing objective biomarkers for concussion, the degree to which they are related has not been systematically investigated in concussed athletes. This study examined whether diffusion metrics differentiated concussed athletes with prolonged recovery (n = 18) from non-conccused athletes (n = 13) and whether observed diffusion alterations related to EEG. Collegiate athletes (N = 31) completed EEG, neurocognitive, and magnetic resonance imaging. White matter diffusivity differed between the groups in multiple white matter tracts, including the corpus callosum, cingulum bundle, thalamic radiations, and inferior fronto-occipital, inferior longitudinal, and uncinate fasciculi, but not after correction for multiple comparisons. The enhanced Brain Function Index (eBFI), a measure that combines EEG and neurocognitive data, significantly correlated with altered diffusion in the concussed athletes. These preliminary findings suggest that the absolute deviation of diffusion metrics in concussed versus non-concussed athletes may have clinically utility. Results also suggested that the eBFI may be sensitive to early changes from sports-related concussion.
KW - brain function index
KW - diffusion tensor imaging
KW - electroencephalography
KW - magnetic resonance imaging
KW - mild traumatic brain injury
KW - sport-related concussion
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U2 - 10.1089/neu.2018.6365
DO - 10.1089/neu.2018.6365
M3 - Article
C2 - 31931657
AN - SCOPUS:85092680348
SN - 0897-7151
VL - 37
SP - 2093
EP - 2101
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 19
ER -