TY - JOUR
T1 - Direct Oral Anticoagulants in the Prevention and Treatment of Venous Thromboembolism in Patients with Cancer
T2 - New Insights from Randomized Controlled Trials
AU - Rojas-Hernandez, Cristhiam M.
AU - Oo, Thein Hlaing
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Cancer accounts for 20% of all venous thromboembolism (VTE) worldwide and cancer patients are at four- to sevenfold increased risk of thrombosis compared to non-cancer patients. VTE is also a morbid complication of cancer and its incidence is rising. Thrombosis is also a second leading cause of death in cancer patients. The standard of care management for the prevention and treatment of cancer-associated thrombosis (CAT) remains the administration of low-molecular-weight heparins (LMWHs). In the last decade, five direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, edoxaban and betrixaban, have been approved for the treatment and prevention of VTE in the general patient population. In this review, we discuss the results of the already published clinical trials with DOACs in the treatment of CAT and the ongoing clinical trials with DOACs in the prevention and treatment of CAT.
AB - Cancer accounts for 20% of all venous thromboembolism (VTE) worldwide and cancer patients are at four- to sevenfold increased risk of thrombosis compared to non-cancer patients. VTE is also a morbid complication of cancer and its incidence is rising. Thrombosis is also a second leading cause of death in cancer patients. The standard of care management for the prevention and treatment of cancer-associated thrombosis (CAT) remains the administration of low-molecular-weight heparins (LMWHs). In the last decade, five direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, edoxaban and betrixaban, have been approved for the treatment and prevention of VTE in the general patient population. In this review, we discuss the results of the already published clinical trials with DOACs in the treatment of CAT and the ongoing clinical trials with DOACs in the prevention and treatment of CAT.
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U2 - 10.1007/s40265-019-01084-2
DO - 10.1007/s40265-019-01084-2
M3 - Review article
C2 - 30905033
AN - SCOPUS:85065343748
SN - 0012-6667
VL - 79
SP - 621
EP - 631
JO - Drugs
JF - Drugs
IS - 6
ER -