@inbook{2c1b34963c47472ba469b8bc15ae8d02,
title = "Discovering functional ERK substrates regulating Caenorhabditis elegans Germline development",
abstract = "The Rat Sarcoma (RAS) GTPAse-mediated extracellular signal-regulated kinase (ERK) pathway regulates multiple biological processes across metazoans. In particular during Caenorhabditis elegans oogenesis, ERK signaling has been shown to regulate over seven distinct biological processes in a temporal and sequential manner. To fully elucidate how ERK signaling cascade orchestrates these different biological processes in vivo, identifi cation of the direct functional substrates of the pathway is critical. This chapter describes the methods that were used to identify ERK substrates in a global manner and study their functions in the germline. These approaches can also be generally applied to study ERK-dependent biological processes in other systems.",
keywords = "C. elegans oogenesis, ERK substrates, Functional genomics",
author = "Chen, {Jessica Jie} and Swathi Arur",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2017.",
year = "2017",
doi = "10.1007/978-1-4939-6424-6_24",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "317--335",
booktitle = "Methods in Molecular Biology",
}