Discovery of 6-[(3 S,4 S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
Barbara Czako, Yuting Sun, Timothy McAfoos, Jason B. Cross, Paul G. Leonard, Jason P. Burke, Christopher L. Carroll, Ningping Feng, Angela L. Harris, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Pijus Mandal, Brooke A. Meyers, Faika Mseeh, Connor A. Parker, Simon S. Yu, Christopher C. Williams, Qi Wu, Maria Emilia Di FrancescoGiulio Draetta, Timothy Heffernan, Joseph R. Marszalek, Nancy E. Kohl, Philip Jones
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