Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors

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4 Scopus citations

Abstract

Purpose: The population of adolescent and young adult (AYA, ages 15–39 years) diffuse large B-cell lymphoma (DLBCL) survivors is growing, however long-term overall survival patterns and disparities are largely unknown. Methods: The current study utilized the Surveillance, Epidemiology, and End Results (SEER) registry to assess the impact of race/ethnicity, sex, socioeconomic status, and rurality on long-term survival in 5-year DLBCL survivors using an accelerated failure time model. Results: Included were 4767 5-year survivors of AYA DLBCL diagnosed between the years 1980 and 2009 with a median follow-up time of 13.4 years. Non-Hispanic Black survivors had significantly worse long-term survival than non-Hispanic White survivors (Survival Time Ratio (STR): 0.53, p < 0.0001). Male sex (STR: 0.57, p < 0.0001) and older age at diagnosis were also associated with reduced long-term survival. There was no evidence that survival disparities improved over time. Conclusions: Racial disparities persist well into survivorship among AYA DLBCL survivors. Studies investigating specific factors associated with survival disparities are urgently needed to better address these disparities.

Original languageEnglish (US)
Article number102044
JournalCancer Epidemiology
Volume75
DOIs
StatePublished - Dec 2021

Keywords

  • AYA
  • Adolescent and Young Adult Oncology
  • Diffuse large B-cell lymphoma
  • Racial disparities
  • Survival

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

MD Anderson CCSG core facilities

  • Biostatistics Resource Group

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