TY - JOUR
T1 - Disseminated cryptococcal infection in allogeneic stem cell transplant patients
T2 - A rare cause of acute kidney injury
AU - Oliver, N.
AU - Luong, T.
AU - Tchakarov, A.
AU - Abdelrahim, M.
AU - Mulanovich, V. E.
AU - Kontoyiannis, D. P.
AU - Jones, R.
AU - Kebriaei, P.
AU - Samuels, J.
AU - Glass, W.
AU - Abudayyeh, A.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.
AB - Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.
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U2 - 10.1038/bmt.2016.120
DO - 10.1038/bmt.2016.120
M3 - Article
C2 - 27159179
AN - SCOPUS:84966650512
SN - 0268-3369
VL - 51
SP - 1301
EP - 1304
JO - Bone marrow transplantation
JF - Bone marrow transplantation
IS - 10
ER -