Disseminating universal genetic testing to a diverse, indigent patient population at a county hospital gynecologic oncology clinic

Erica M. Bednar, Charlotte C. Sun, Bethsaida Camacho, John Terrell, Alyssa G. Rieber, Lois M. Ramondetta, Ralph S. Freedman, Karen H. Lu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The universal genetic testing initiative (UGTI) is a quality improvement effort to increase rates of guideline-based genetic counseling (GC) and genetic testing (GT) of patients with potentially hereditary cancers. The UGTI was disseminated to a county hospital gynecologic oncology clinic that serves a diverse, indigent patient population. Methods: Using the Model for Improvement quality improvement framework, interventions including integrated GC, clinic tracking, assisted GC referrals, and provider education were tested over 26 months. A retrospective data review included patients with high-grade, non-mucinous epithelial ovarian, fallopian tube, and primary peritoneal cancers (HGOC) and endometrial cancers (EC) diagnosed between 9/1/12–8/31/16. Statistical analyses were performed to describe the population and to evaluate rates of recommendation and use of immunohistochemistry tumor testing (IHC), GC, and GT. Results: A cohort of 241 patients (57 HGOC, 184 EC) were included. At the conclusion of the study 84.2% of HGOC patients were referred for GC, 89.6% (43/48) completed GC, and 90.7% (39/43) completed GT. Of EC patients, 81.0% were recommended to have IHC and 62.4% (93/149) completed IHC. Patients with HGOC diagnosed during dissemination of UGTI were significantly more likely to receive a recommendation for GC (p = 0.02) and to complete GT (p = 0.03) than those diagnosed before UGTI. Patients with EC were significantly more likely to complete IHC if diagnosed after UGTI than those diagnosed prior to dissemination (p < 0.001). Conclusions: The UGTI can be adapted to increase use of guideline-based cancer genetics services in a diverse, indigent, gynecologic cancer patient population.

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalGynecologic oncology
Volume152
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • Endometrial cancer
  • Genetic counseling
  • Genetic testing
  • Ovarian cancer
  • Quality improvement

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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