Do comorbid psychiatric disorders contribute to the pathogenesis of tako-tsubo syndrome? A review of pathogenesis

Sun B. Nguyen, Cihan Cevik, Mohammad Otahbachi, Ashwani Kumar, Leigh Ann Jenkins, Kenneth Nugent

    Research output: Contribution to journalReview article

    29 Citations (Scopus)

    Abstract

    Patients with tako-tsubo cardiomyopathy have unusual characteristics, including a disproportionate occurrence in postmenopausal women and a strong association with mental and physical stress. These patients present with chest pain, abnormal electrocardiographic findings, and myocardial enzyme leaks. They appear to have acute coronary syndrome but have normal epicardial coronary vessels and reversible left ventricular dysfunction. High circulating levels of catecholamines likely cause this syndrome through direct injury of myocardial cells. The frequent occurrence in postmenopausal women has not been explained. This association might reflect changes in autonomic control of the cardiovascular system and in baroreceptor sensitivity in postmenopausal women. Women in this age group also have a high frequency of both depression and anxiety. These 2 psychiatric diagnoses are associated with episodic symptoms, including acute panic attacks, which can be associated with catecholamine release in the heart. Therefore, tako-tsubo cardiomyopathy may occur in postmenopausal women as a consequence of comorbid psychiatric diagnoses and normal age-related changes in autonomic control of the cardiovascular system. This hypothesis warrants prospective case-control studies.

    Original languageEnglish (US)
    Pages (from-to)31-34
    Number of pages4
    JournalCongestive Heart Failure
    Volume15
    Issue number1
    DOIs
    StatePublished - Feb 9 2009

    Fingerprint

    Takotsubo Cardiomyopathy
    Psychiatry
    Cardiovascular System
    Mental Disorders
    Catecholamines
    Pressoreceptors
    Panic Disorder
    Left Ventricular Dysfunction
    Acute Coronary Syndrome
    Chest Pain
    Case-Control Studies
    Coronary Vessels
    Anxiety
    Age Groups
    Depression
    Wounds and Injuries
    Enzymes

    ASJC Scopus subject areas

    • Emergency Medicine
    • Emergency
    • Cardiology and Cardiovascular Medicine

    Cite this

    Do comorbid psychiatric disorders contribute to the pathogenesis of tako-tsubo syndrome? A review of pathogenesis. / Nguyen, Sun B.; Cevik, Cihan; Otahbachi, Mohammad; Kumar, Ashwani; Jenkins, Leigh Ann; Nugent, Kenneth.

    In: Congestive Heart Failure, Vol. 15, No. 1, 09.02.2009, p. 31-34.

    Research output: Contribution to journalReview article

    Nguyen, Sun B. ; Cevik, Cihan ; Otahbachi, Mohammad ; Kumar, Ashwani ; Jenkins, Leigh Ann ; Nugent, Kenneth. / Do comorbid psychiatric disorders contribute to the pathogenesis of tako-tsubo syndrome? A review of pathogenesis. In: Congestive Heart Failure. 2009 ; Vol. 15, No. 1. pp. 31-34.
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    AU - Jenkins, Leigh Ann

    AU - Nugent, Kenneth

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