[Docetaxel plus prednisone versus mitoxantrone plus prednisone as first-line chemotherapy for metastatic hormone-refractory prostate cancer: long-term effects and safety].

Yi jun Shen, Xiao jie Bian, Hu yang Xie, Yao Zhu, Hai liang Zhang, B. Dai, Shi lin Zhang, Xu dong Yao, Ding wei Ye

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    Abstract

    To compare docetaxel plus prednisone with mitoxantrone plus prednisone as first-line chemotherapy for metastatic hormone-refractory prostate cancer (mHRPC). From January 2007 through August 2010, 62 patients with mHRPC received 5 mg of prednisone twice daily were randomly assigned to receive mitoxantrone 12 mg/m2 every three weeks (group A) or 75 mg/m2 every three weeks (group B). The cycles of each regimen were less than 10 times. The primary end point was overall survival. The secondary end points were the prostate-specific antigen (PSA) response rate, the duration of PSA response and the objective tumor response rate (ORR). All the t test, χ2 test and Fisher's exact test were performed between 2 groups. Thirty-one patients enrolled in group A received a median 4 cycles of regimen (range 1 - 10), whereas 30 patients enrolled in group B received a median of 7 cycles of regimen (range 2 - 10). There were 45.2% patients in group A and 70.0% in group B had PSA response (χ2 = 3.85, P < 0.05). The duration time of PSA response was 121 days (range 20-323 days) in group A and 168 days (range 42 - 447 days) in group B, respectively. The ORR was 15.0(3/20) in group A and 10.3% (3/29) in group B, respectively. The median survival was 511 days (95%CI: 357 - 665 days) in group A and 833 days (95%CI: 634 - 1032 days) in group B, respectively (χ2 = 4.20, P = 0.040). The incidence of thrombocytopenia in group A was higher than group B (χ2 = 5.60, P = 0.018); the incidences of nausea and vomiting (χ2 = 4.32, P = 0.038), diarrhea (P = 0.024), fatigue (χ2 = 5.90, P = 0.015), and alopecia (χ2 = 5.42, P = 0.020) in group B were higher than group A. Docetaxel plus prednisone can lead to superior overall survival and PSA response rate in patients with mHRPC.

    Original languageEnglish (US)
    Pages (from-to)539-542
    Number of pages4
    JournalZhonghua wai ke za zhi [Chinese journal of surgery]
    Volume50
    Issue number6
    StatePublished - Jun 2012

    ASJC Scopus subject areas

    • Medicine(all)

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