Abstract
Background: Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of Dox@HAuNS followed by photothermal ablation (PTA) in a rabbit model of liver cancer. Adult New Zealand white rabbits (N = 25) were inoculated with VX2 tumors into the left lobe of the liver. The animals were then randomized to sham surgery (N = 5), PTA only (N = 3), Dox@HAuNS only (N = 5), HAuNS + PTA (N = 5), and Dox@HAuNS + PTA (N = 7). Nanoparticles were delivered as an emulsion with Lipiodol (Guerbet, France) via a trans-arterial approach. Following nanoparticle delivery, PTA was performed using an 808-nm fibered laser at 1.5 W for 3 min. Thermography during PTA demonstrated a sustained elevation in tumoral temperature in both HAuNS + laser and Dox@HAuNS + laser treatment groups relative to animals that underwent laser treatment without prior nanoparticle delivery. Results: There was a significant decrease in tumor volumes in all three treatment arms relative to control arms (P = 0.004). Concentrations of intratumoral doxorubicin were significantly greater in animals treated with laser compared to those that were not treated with laser (P < 0.01). Conclusions: Doxorubicin-loaded HAuNS is a promising therapeutic agent for dual ablation/chemoembolization treatment of liver cancer.
Original language | English (US) |
---|---|
Article number | 6 |
Journal | Cancer Nanotechnology |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2020 |
Keywords
- Drug delivery
- Gold nanoparticles
- Hepatocellular carcinoma
- Thermal ablation
- Transarterial delivery
ASJC Scopus subject areas
- Biomedical Engineering
- Oncology
- Pharmaceutical Science
- Physical and Theoretical Chemistry
MD Anderson CCSG core facilities
- Research Animal Support Facility
- Small Animal Imaging Facility