Abstract
T cells that have been genetically modified, activated, and propagated ex vivo can be infused to control tumor progression in patients who are refractory to conventional treatments. Early-phase clinical trials demonstrate that the tumor-associated antigen (TAA) CD19 can be therapeutically engaged through the enforced expression of a chimeric antigen receptor (CAR) on clinical-grade T cells. Advances in vector design, the architecture of the CAR molecule especially as associated with T-cell co-stimulatory pathways, and understanding of the tumor microenvironment, play significant roles in the successful treatment of medically fragile patients. However, some recipients of CAR + T cells demonstrate incomplete responses. Understanding the potential for treatment failure provides a pathway to improve the potency of adoptive transfer of CAR+ T cells. High throughput single-cell analyses to understand the complexity of the inoculum coupled with animal models may provide insight into the therapeutic potential of genetically modified T cells. This review focusses on recent advances regarding the human application of CD19-specific CAR+ T cells and explores how their success for hematologic cancers can provide a framework for investigational treatment of solid tumor malignancies.
Original language | English (US) |
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Pages (from-to) | 50-56 |
Number of pages | 7 |
Journal | Current hematologic malignancy reports |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2014 |
Keywords
- B-cell malignancies
- Chimeric antigen receptor
- Gene therapy
- T-cell therapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
MD Anderson CCSG core facilities
- Monoclonal Antibody Facility