TY - JOUR
T1 - Drug delivery and tissue engineering to promote wound healing in the immunocompromised host
T2 - Current challenges and future directions
AU - Tatara, Alexander M.
AU - Kontoyiannis, Dimitrios P.
AU - Mikos, Antonios G.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/4
Y1 - 2018/4
N2 - As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Specifically, patients suffering from diabetes, malignancy, human immunodeficiency virus, post-organ transplantation, and other compromised states have significant pleotropic immune defects that affect wound healing. In this work, we review the role of different immune cells in the regenerative process, highlight the effect of several common immunocompromised states on wound healing, and discuss different drug delivery strategies for overcoming immunodeficiencies.
AB - As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Specifically, patients suffering from diabetes, malignancy, human immunodeficiency virus, post-organ transplantation, and other compromised states have significant pleotropic immune defects that affect wound healing. In this work, we review the role of different immune cells in the regenerative process, highlight the effect of several common immunocompromised states on wound healing, and discuss different drug delivery strategies for overcoming immunodeficiencies.
KW - Immunity
KW - Immunodeficient
KW - Immunosuppression
KW - Infection
KW - Regenerative medicine
KW - Tissue engineering
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U2 - 10.1016/j.addr.2017.12.001
DO - 10.1016/j.addr.2017.12.001
M3 - Review article
C2 - 29221962
AN - SCOPUS:85037746057
SN - 0169-409X
VL - 129
SP - 319
EP - 329
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -