Drug-MicroRNA Cross-Talk

Paloma del C. Monroig; George A. Calin

doi:10.1016/B978-0-12-405544-5.00038-1

Drug-MicroRNA Cross-Talk

Paloma del C. Monroig, George A. Calin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Regenerative medicine is an interdisciplinary field that aims to repair, replace, or regenerate cells, tissues, or organs that are lost or damaged because of disease, injury, or aging. Understanding the roles of microRNAs (miRNAs) in these biological processes is thus a novel therapeutic approach. Several drugs can alter basal levels of miRNAs in a tissue-dependent manner, causing some miRNAs to increase and others to nearly disappear. When miRNA levels are altered during treatment, their expression can determine whether or not a therapy is successful. Key interactions that link miRNAs in drug efficacy and toxicity are outlined in this chapter. By understanding the pharmacogenomic mechanisms involving miRNAs and drugs, researchers aim to elucidate potential clinical applications in regenerative medicine.

Original language	English (US)
Title of host publication	MicroRNA in Regenerative Medicine
Publisher	Elsevier Inc.
Pages	991-1016
Number of pages	26
ISBN (Electronic)	9780124058583
ISBN (Print)	9780124055445
DOIs	https://doi.org/10.1016/B978-0-12-405544-5.00038-1
State	Published - 2015

Keywords

Drug efficacy
Drug metabolism
Drug toxicity
MiRNAs
MicroRNAs
Pharmacogenomics
Protein regulation
Regenerative medicine

ASJC Scopus subject areas

General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-405544-5.00038-1

Cite this

@inbook{6f9f21d35f0e4627974a618236e5bab9,

title = "Drug-MicroRNA Cross-Talk",

abstract = "Regenerative medicine is an interdisciplinary field that aims to repair, replace, or regenerate cells, tissues, or organs that are lost or damaged because of disease, injury, or aging. Understanding the roles of microRNAs (miRNAs) in these biological processes is thus a novel therapeutic approach. Several drugs can alter basal levels of miRNAs in a tissue-dependent manner, causing some miRNAs to increase and others to nearly disappear. When miRNA levels are altered during treatment, their expression can determine whether or not a therapy is successful. Key interactions that link miRNAs in drug efficacy and toxicity are outlined in this chapter. By understanding the pharmacogenomic mechanisms involving miRNAs and drugs, researchers aim to elucidate potential clinical applications in regenerative medicine.",

keywords = "Drug efficacy, Drug metabolism, Drug toxicity, MiRNAs, MicroRNAs, Pharmacogenomics, Protein regulation, Regenerative medicine",

author = "Monroig, {Paloma del C.} and Calin, {George A.}",

year = "2015",

doi = "10.1016/B978-0-12-405544-5.00038-1",

language = "English (US)",

isbn = "9780124055445",

pages = "991--1016",

booktitle = "MicroRNA in Regenerative Medicine",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Drug-MicroRNA Cross-Talk

AU - Monroig, Paloma del C.

AU - Calin, George A.

PY - 2015

Y1 - 2015

N2 - Regenerative medicine is an interdisciplinary field that aims to repair, replace, or regenerate cells, tissues, or organs that are lost or damaged because of disease, injury, or aging. Understanding the roles of microRNAs (miRNAs) in these biological processes is thus a novel therapeutic approach. Several drugs can alter basal levels of miRNAs in a tissue-dependent manner, causing some miRNAs to increase and others to nearly disappear. When miRNA levels are altered during treatment, their expression can determine whether or not a therapy is successful. Key interactions that link miRNAs in drug efficacy and toxicity are outlined in this chapter. By understanding the pharmacogenomic mechanisms involving miRNAs and drugs, researchers aim to elucidate potential clinical applications in regenerative medicine.

AB - Regenerative medicine is an interdisciplinary field that aims to repair, replace, or regenerate cells, tissues, or organs that are lost or damaged because of disease, injury, or aging. Understanding the roles of microRNAs (miRNAs) in these biological processes is thus a novel therapeutic approach. Several drugs can alter basal levels of miRNAs in a tissue-dependent manner, causing some miRNAs to increase and others to nearly disappear. When miRNA levels are altered during treatment, their expression can determine whether or not a therapy is successful. Key interactions that link miRNAs in drug efficacy and toxicity are outlined in this chapter. By understanding the pharmacogenomic mechanisms involving miRNAs and drugs, researchers aim to elucidate potential clinical applications in regenerative medicine.

KW - Drug efficacy

KW - Drug metabolism

KW - Drug toxicity

KW - MiRNAs

KW - MicroRNAs

KW - Pharmacogenomics

KW - Protein regulation

KW - Regenerative medicine

UR - http://www.scopus.com/inward/record.url?scp=84943340023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943340023&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-405544-5.00038-1

DO - 10.1016/B978-0-12-405544-5.00038-1

M3 - Chapter

AN - SCOPUS:84943340023

SN - 9780124055445

SP - 991

EP - 1016

BT - MicroRNA in Regenerative Medicine

PB - Elsevier Inc.

ER -

Drug-MicroRNA Cross-Talk

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this