Abstract
Overlapping fibroglandular tissue structures may obscure small calcifications, essential to the early detection of breast cancer. Dual-energy digital mammography (DEDM), where separate low- and high-energy images are acquired and synthesized to cancel the tissue structures, may improve the ability to detect and visualize calcifications amidst fibroglandular structures. We have developed and implemented a DEDM technique under full-field imaging conditions using a commercially available flat-panel based digital mammography system. We have developed techniques to suppress residual structures due to scatter contamination and non-uniformity in the x-ray field and detector response in our DEDM implementation. The total mean-glandular dose from the low- and high-energy images was constrained to be similar to screening examination levels. The low- and high-energy images were combined using a calibrated nonlinear (cubic) mapping function to generate the calcification images. To evaluate the dual-energy calcification images, we have designed a special phantom with calcium carbonate crystals to simulate calcifications of different sizes superimposed with a 5 cm thick breast-tissue-equivalent material with a continuously varying glandular-tissue ratio from 0.0 to 1.0. The suppression of tissue-structure background by dual-energy imaging comes with the cost of increased noise hi the dual-energy images. We report on the effects of different image processing techniques on the dual-energy image signal and noise levels. The effects of image processing on the calcification contrast-to-noise ratios are also presented.
Original language | English (US) |
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Article number | 158 |
Pages (from-to) | 1342-1350 |
Number of pages | 9 |
Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 5745 |
Issue number | II |
DOIs | |
State | Published - 2005 |
Event | Medical Imaging 2005 - Physics of Medical Imaging - San Diego, CA, United States Duration: Feb 13 2005 → Feb 15 2005 |
Keywords
- Calcifications
- Digital imaging
- Dual-energy
- Inverse-mapping
- Mammography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging