Dynamic contrast-enhanced MRI in patients with brain metastases undergoing laser interstitial thermal therapy: A pilot study

J. I. Traylor, D. C.A. Bastos, D. Fuentes, M. Muir, R. Patel, V. A. Kumar, R. J. Stafford, G. Rao, S. S. Prabhu

Research output: Contribution to journalArticle

Abstract

BACKGROUNDANDPURPOSE: Tumor recurrence is difficult to predict in patients receiving laser ablation for intracranial malignancy.We assessed the efficacy of the initial area under the time-to-signal intensity curve at 60 seconds (iAUC60) from dynamic contrast-enhanced MR imaging in predicting progression-free survival in patients with brain metastases following laser interstitial thermal therapy. MATERIALS AND METHODS: The study population was a consecutive series of patients undergoing laser interstitial thermal therapy for brain metastases. Patient demographics including age, sex, tumor histology, and Karnofsky Performance Scale were collected prospectively. Preoperative, postoperative, and 1-month follow-up dynamic contrast-enhanced MRIs were analyzed. Values of iAUC60 were computed using a trapezoidal rule applied to the time history of contrast uptake over the first 60 seconds postenhancement. The change in iAUC60 (ΔiAUC60) was calculated by taking the difference between the values of iAUC60 from 2 time points. Pearson correlation coefficients were calculated between progression-free survival, defined as the time from laser interstitial thermal therapy to tumor recurrence, and iAUC60 or ΔiAUC60 values. RESULTS: Thirty-three cases of laser interstitial thermal therapy for 32 brain metastases in a cohort of 27 patients were prospectively analyzed. A significant relationship was observed between the values of iAUC60 from postoperative dynamic contrast-enhanced MR imaging and progression-free survival with Pearson correlation (P = .03) and Cox univariate analysis (P = .01). The relationship between preoperative and 1-month follow-up dynamic contrast-enhanced MR imaging was not significantly correlated with progression-free survival. Similarly, no statistically significant relationship was observed with ΔiAUC60 and progression-free survival between any time points. CONCLUSIONS: Progression-free survival is difficult to predict in patients undergoing laser interstitial thermal therapy for brain metastases due to confounding with posttreatment change. iAUC60 extracted from postoperative dynamic contrast-enhanced MR imaging shows promise for accurately prognosticating patients following this operative therapy.

Original languageEnglish (US)
Pages (from-to)1451-1457
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume40
Issue number9
DOIs
StatePublished - Jan 1 2019

Fingerprint

Lasers
Disease-Free Survival
Hot Temperature
Neoplasm Metastasis
Brain
Therapeutics
Neoplasms
Karnofsky Performance Status
Recurrence
Laser Therapy
Histology
Demography
Population

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Dynamic contrast-enhanced MRI in patients with brain metastases undergoing laser interstitial thermal therapy : A pilot study. / Traylor, J. I.; Bastos, D. C.A.; Fuentes, D.; Muir, M.; Patel, R.; Kumar, V. A.; Stafford, R. J.; Rao, G.; Prabhu, S. S.

In: American Journal of Neuroradiology, Vol. 40, No. 9, 01.01.2019, p. 1451-1457.

Research output: Contribution to journalArticle

@article{adaaf76bbef04b8788c9d4fba7925430,
title = "Dynamic contrast-enhanced MRI in patients with brain metastases undergoing laser interstitial thermal therapy: A pilot study",
abstract = "BACKGROUNDANDPURPOSE: Tumor recurrence is difficult to predict in patients receiving laser ablation for intracranial malignancy.We assessed the efficacy of the initial area under the time-to-signal intensity curve at 60 seconds (iAUC60) from dynamic contrast-enhanced MR imaging in predicting progression-free survival in patients with brain metastases following laser interstitial thermal therapy. MATERIALS AND METHODS: The study population was a consecutive series of patients undergoing laser interstitial thermal therapy for brain metastases. Patient demographics including age, sex, tumor histology, and Karnofsky Performance Scale were collected prospectively. Preoperative, postoperative, and 1-month follow-up dynamic contrast-enhanced MRIs were analyzed. Values of iAUC60 were computed using a trapezoidal rule applied to the time history of contrast uptake over the first 60 seconds postenhancement. The change in iAUC60 (ΔiAUC60) was calculated by taking the difference between the values of iAUC60 from 2 time points. Pearson correlation coefficients were calculated between progression-free survival, defined as the time from laser interstitial thermal therapy to tumor recurrence, and iAUC60 or ΔiAUC60 values. RESULTS: Thirty-three cases of laser interstitial thermal therapy for 32 brain metastases in a cohort of 27 patients were prospectively analyzed. A significant relationship was observed between the values of iAUC60 from postoperative dynamic contrast-enhanced MR imaging and progression-free survival with Pearson correlation (P = .03) and Cox univariate analysis (P = .01). The relationship between preoperative and 1-month follow-up dynamic contrast-enhanced MR imaging was not significantly correlated with progression-free survival. Similarly, no statistically significant relationship was observed with ΔiAUC60 and progression-free survival between any time points. CONCLUSIONS: Progression-free survival is difficult to predict in patients undergoing laser interstitial thermal therapy for brain metastases due to confounding with posttreatment change. iAUC60 extracted from postoperative dynamic contrast-enhanced MR imaging shows promise for accurately prognosticating patients following this operative therapy.",
author = "Traylor, {J. I.} and Bastos, {D. C.A.} and D. Fuentes and M. Muir and R. Patel and Kumar, {V. A.} and Stafford, {R. J.} and G. Rao and Prabhu, {S. S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.3174/ajnr.A6144",
language = "English (US)",
volume = "40",
pages = "1451--1457",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "9",

}

TY - JOUR

T1 - Dynamic contrast-enhanced MRI in patients with brain metastases undergoing laser interstitial thermal therapy

T2 - A pilot study

AU - Traylor, J. I.

AU - Bastos, D. C.A.

AU - Fuentes, D.

AU - Muir, M.

AU - Patel, R.

AU - Kumar, V. A.

AU - Stafford, R. J.

AU - Rao, G.

AU - Prabhu, S. S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUNDANDPURPOSE: Tumor recurrence is difficult to predict in patients receiving laser ablation for intracranial malignancy.We assessed the efficacy of the initial area under the time-to-signal intensity curve at 60 seconds (iAUC60) from dynamic contrast-enhanced MR imaging in predicting progression-free survival in patients with brain metastases following laser interstitial thermal therapy. MATERIALS AND METHODS: The study population was a consecutive series of patients undergoing laser interstitial thermal therapy for brain metastases. Patient demographics including age, sex, tumor histology, and Karnofsky Performance Scale were collected prospectively. Preoperative, postoperative, and 1-month follow-up dynamic contrast-enhanced MRIs were analyzed. Values of iAUC60 were computed using a trapezoidal rule applied to the time history of contrast uptake over the first 60 seconds postenhancement. The change in iAUC60 (ΔiAUC60) was calculated by taking the difference between the values of iAUC60 from 2 time points. Pearson correlation coefficients were calculated between progression-free survival, defined as the time from laser interstitial thermal therapy to tumor recurrence, and iAUC60 or ΔiAUC60 values. RESULTS: Thirty-three cases of laser interstitial thermal therapy for 32 brain metastases in a cohort of 27 patients were prospectively analyzed. A significant relationship was observed between the values of iAUC60 from postoperative dynamic contrast-enhanced MR imaging and progression-free survival with Pearson correlation (P = .03) and Cox univariate analysis (P = .01). The relationship between preoperative and 1-month follow-up dynamic contrast-enhanced MR imaging was not significantly correlated with progression-free survival. Similarly, no statistically significant relationship was observed with ΔiAUC60 and progression-free survival between any time points. CONCLUSIONS: Progression-free survival is difficult to predict in patients undergoing laser interstitial thermal therapy for brain metastases due to confounding with posttreatment change. iAUC60 extracted from postoperative dynamic contrast-enhanced MR imaging shows promise for accurately prognosticating patients following this operative therapy.

AB - BACKGROUNDANDPURPOSE: Tumor recurrence is difficult to predict in patients receiving laser ablation for intracranial malignancy.We assessed the efficacy of the initial area under the time-to-signal intensity curve at 60 seconds (iAUC60) from dynamic contrast-enhanced MR imaging in predicting progression-free survival in patients with brain metastases following laser interstitial thermal therapy. MATERIALS AND METHODS: The study population was a consecutive series of patients undergoing laser interstitial thermal therapy for brain metastases. Patient demographics including age, sex, tumor histology, and Karnofsky Performance Scale were collected prospectively. Preoperative, postoperative, and 1-month follow-up dynamic contrast-enhanced MRIs were analyzed. Values of iAUC60 were computed using a trapezoidal rule applied to the time history of contrast uptake over the first 60 seconds postenhancement. The change in iAUC60 (ΔiAUC60) was calculated by taking the difference between the values of iAUC60 from 2 time points. Pearson correlation coefficients were calculated between progression-free survival, defined as the time from laser interstitial thermal therapy to tumor recurrence, and iAUC60 or ΔiAUC60 values. RESULTS: Thirty-three cases of laser interstitial thermal therapy for 32 brain metastases in a cohort of 27 patients were prospectively analyzed. A significant relationship was observed between the values of iAUC60 from postoperative dynamic contrast-enhanced MR imaging and progression-free survival with Pearson correlation (P = .03) and Cox univariate analysis (P = .01). The relationship between preoperative and 1-month follow-up dynamic contrast-enhanced MR imaging was not significantly correlated with progression-free survival. Similarly, no statistically significant relationship was observed with ΔiAUC60 and progression-free survival between any time points. CONCLUSIONS: Progression-free survival is difficult to predict in patients undergoing laser interstitial thermal therapy for brain metastases due to confounding with posttreatment change. iAUC60 extracted from postoperative dynamic contrast-enhanced MR imaging shows promise for accurately prognosticating patients following this operative therapy.

UR - http://www.scopus.com/inward/record.url?scp=85071784654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071784654&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A6144

DO - 10.3174/ajnr.A6144

M3 - Article

C2 - 31371353

AN - SCOPUS:85071784654

VL - 40

SP - 1451

EP - 1457

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 9

ER -