Dynamic regulation of nucleolar architecture

Attila Németh, Ingrid Grummt

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle progression and senses environmental stress. The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture. The intimate link between nucleolar structure and function is reflected by transcription-dependent changes in nucleolus-associated chromatin, overall morphological alterations in response to external cues, and the liquid droplet-like behavior of nucleolar compartments. Here we provide a concise overview of the latest studies which integrate novel trends in nucleolar architecture research into the context of cell biology.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume52
DOIs
StatePublished - Jun 1 2018

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Ribonucleoproteins
Nuclear Proteins
Cell Cycle Checkpoints
Ribosomes
Chromatin
Cues
Cell Biology
RNA
Research

ASJC Scopus subject areas

  • Cell Biology

Cite this

Dynamic regulation of nucleolar architecture. / Németh, Attila; Grummt, Ingrid.

In: Current Opinion in Cell Biology, Vol. 52, 01.06.2018, p. 105-111.

Research output: Contribution to journalReview article

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