@inbook{c49cc183138f4092a32fdd3ae65f441d,
title = "Dynamics of histone lysine methylation: Structures of methyl writers and erasers",
abstract = "In Eukarya, the packaging of DNA into chromatin provides a barrier that allows for regulation of access to the genome. Chromatin is refractory to processes acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines (the focus of this chapter). These lysine marks are generated by a host of histone lysine methyltransferases (writers) and can be removed by histone lysine demethylases (erasers). Importantly, epigenetic modifications impact chromatin structure directly or can be read by effector regulatory modules. Here, we summarize current knowledge on structural and functional properties of various histone lysine methyltransfereases and demethylases, with emphasis on their importance as druggable targets.",
author = "Upadhyay, {Anup K.} and Xiaodong Cheng",
note = "Funding Information: The work in the Cheng laboratory was supported by grants GM06860 and DK082678 from the National Institutes of Health (NIH). X.C. is a Georgia Research Alliance Eminent Scholar.",
year = "2011",
doi = "10.1007/978-3-7643-8989-5_6",
language = "English (US)",
isbn = "9783764389888",
series = "Progress in Drug Research",
pages = "107--124",
editor = "Susan Gasser and En Li",
booktitle = "Epigenetics and Disease",
}