Dynamics of histone lysine methylation: Structures of methyl writers and erasers

Anup K. Upadhyay, Xiaodong Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter

47 Scopus citations

Abstract

In Eukarya, the packaging of DNA into chromatin provides a barrier that allows for regulation of access to the genome. Chromatin is refractory to processes acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines (the focus of this chapter). These lysine marks are generated by a host of histone lysine methyltransferases (writers) and can be removed by histone lysine demethylases (erasers). Importantly, epigenetic modifications impact chromatin structure directly or can be read by effector regulatory modules. Here, we summarize current knowledge on structural and functional properties of various histone lysine methyltransfereases and demethylases, with emphasis on their importance as druggable targets.

Original languageEnglish (US)
Title of host publicationEpigenetics and Disease
Subtitle of host publicationPharmaceutical Opportunities
EditorsSusan Gasser, En Li
Pages107-124
Number of pages18
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameProgress in Drug Research
Volume67
ISSN (Print)0071-786X

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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