Early history of Neanderthals and Denisovans

Alan R. Rogers; Ryan J. Bohlender; Chad D. Huff

doi:10.1073/pnas.1706426114

Early history of Neanderthals and Denisovans

Alan R. Rogers, Ryan J. Bohlender, Chad D. Huff

Epidemiology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Extensive DNA sequence data have made it possible to reconstruct human evolutionary history in unprecedented detail. We introduce a method to study the past several hundred thousand years. Our results show that (i) the Neanderthal–Denisovan lineage declined to a small size just after separating from the modern lineage, (ii) Neanderthals and Denisovans separated soon thereafter, and (iii) the subsequent Neanderthal population was large and deeply subdivided. They also (iv) support previous estimates of gene flow from Neanderthals into modern Eurasians. These results suggest an archaic human diaspora early in the Middle Pleistocene.

Original language	English (US)
Pages (from-to)	9859-9863
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	114
Issue number	37
DOIs	https://doi.org/10.1073/pnas.1706426114
State	Published - Sep 12 2017

Keywords

Archaic admixture
Denisovans
Human evolution
Introgression
Neanderthals

ASJC Scopus subject areas

General

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10.1073/pnas.1706426114

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title = "Early history of Neanderthals and Denisovans",

abstract = "Extensive DNA sequence data have made it possible to reconstruct human evolutionary history in unprecedented detail. We introduce a method to study the past several hundred thousand years. Our results show that (i) the Neanderthal–Denisovan lineage declined to a small size just after separating from the modern lineage, (ii) Neanderthals and Denisovans separated soon thereafter, and (iii) the subsequent Neanderthal population was large and deeply subdivided. They also (iv) support previous estimates of gene flow from Neanderthals into modern Eurasians. These results suggest an archaic human diaspora early in the Middle Pleistocene.",

keywords = "Archaic admixture, Denisovans, Human evolution, Introgression, Neanderthals",

author = "Rogers, {Alan R.} and Bohlender, {Ryan J.} and Huff, {Chad D.}",

note = "Funding Information: ACKNOWLEDGMENTS. We are grateful for comments from Elizabeth Cashdan, Lounes Chikhi, Mitchell Lokey, Nala Rogers, Jon Seger, and Serena Tucci. A.R.R. was supported by National Science Foundation Award BCS 1638840 and by the Center for High Performance Computing at the University of Utah. R.J.B. was supported by National Cancer Institute Awards R25CA057730 (PI: Shine Chang, PhD) and CA016672 (Principal investigator: Ronald Depinho, MD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2017, National Academy of Sciences. All rights reserved.",

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doi = "10.1073/pnas.1706426114",

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AU - Rogers, Alan R.

AU - Bohlender, Ryan J.

AU - Huff, Chad D.

N1 - Funding Information: ACKNOWLEDGMENTS. We are grateful for comments from Elizabeth Cashdan, Lounes Chikhi, Mitchell Lokey, Nala Rogers, Jon Seger, and Serena Tucci. A.R.R. was supported by National Science Foundation Award BCS 1638840 and by the Center for High Performance Computing at the University of Utah. R.J.B. was supported by National Cancer Institute Awards R25CA057730 (PI: Shine Chang, PhD) and CA016672 (Principal investigator: Ronald Depinho, MD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2017, National Academy of Sciences. All rights reserved.

PY - 2017/9/12

Y1 - 2017/9/12

N2 - Extensive DNA sequence data have made it possible to reconstruct human evolutionary history in unprecedented detail. We introduce a method to study the past several hundred thousand years. Our results show that (i) the Neanderthal–Denisovan lineage declined to a small size just after separating from the modern lineage, (ii) Neanderthals and Denisovans separated soon thereafter, and (iii) the subsequent Neanderthal population was large and deeply subdivided. They also (iv) support previous estimates of gene flow from Neanderthals into modern Eurasians. These results suggest an archaic human diaspora early in the Middle Pleistocene.

AB - Extensive DNA sequence data have made it possible to reconstruct human evolutionary history in unprecedented detail. We introduce a method to study the past several hundred thousand years. Our results show that (i) the Neanderthal–Denisovan lineage declined to a small size just after separating from the modern lineage, (ii) Neanderthals and Denisovans separated soon thereafter, and (iii) the subsequent Neanderthal population was large and deeply subdivided. They also (iv) support previous estimates of gene flow from Neanderthals into modern Eurasians. These results suggest an archaic human diaspora early in the Middle Pleistocene.

KW - Archaic admixture

KW - Denisovans

KW - Human evolution

KW - Introgression

KW - Neanderthals

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Early history of Neanderthals and Denisovans

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