TY - JOUR
T1 - Early lymphocyte recovery as a prognostic indicator for high-risk Ewing sarcoma
AU - De Angulo, Guillermo
AU - Hernandez, Mike
AU - Morales-Arias, Jaime
AU - Herzog, Cynthia E.
AU - Anderson, Peter
AU - Wolff, Johannes
AU - Kleinerman, Eugenie S.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - BACKGROUND: Increasing evidence suggests that lymphocyte recovery plays a major part in tumor control. Facilitating immune reconstitution might be a novel direction of cancer therapy. The purpose of this study was to determine if early lymphocyte recovery is an independent prognostic indicator for high-risk Ewing sarcoma outcome. RESULTS: Data of 24 Ewing sarcoma patients were analyzed (age, 3 to 50 y; median, 16.5; male to female, 16:8). The 5-year overall survival (OS) of the total population was 47.9% [10.6 standard error (SE)]. Patients were separated into 2 groups: prolonged lymphopenia versus early lymphocyte recovery, using a threshold absolute lymphocyte count (ALC) of ≥500 cells/μL on day 15. The majority (67%; n=16) of the patients had an ALC ≥500 cells/μL, and of these 10/16 are alive with a 5-year OS of 58.7% (13.2 SE). In contrast, 33% (n=8) of patients had an ALC <500 cells/μL on day 15 and only 2/8 are alive with a 5-year OS of 25% (15.3 SE). This difference was significant (P=0.007 using the log rank test). When comparing patients with metastatic disease, patients with an ALC-15 <500 cells/μL had a median survival of 13 months, whereas patients with an ALC-15 ≥500 cells/μL had a median survival of 29.5 months. All patients had an ALC before chemotherapy of >1000 cells/μL. The difference was significant (P value=0.001 using the log rank test). Univariate analysis of platelet counts, age, sex, and absolute neutrophil count showed no statistically significant association with OS. CONCLUSIONS: The data demonstrate that an ALC ≥500 cells/μL on day 15 of the first course of chemotherapy is an independent prognostic factor associated with superior OS in high-risk Ewing sarcoma.
AB - BACKGROUND: Increasing evidence suggests that lymphocyte recovery plays a major part in tumor control. Facilitating immune reconstitution might be a novel direction of cancer therapy. The purpose of this study was to determine if early lymphocyte recovery is an independent prognostic indicator for high-risk Ewing sarcoma outcome. RESULTS: Data of 24 Ewing sarcoma patients were analyzed (age, 3 to 50 y; median, 16.5; male to female, 16:8). The 5-year overall survival (OS) of the total population was 47.9% [10.6 standard error (SE)]. Patients were separated into 2 groups: prolonged lymphopenia versus early lymphocyte recovery, using a threshold absolute lymphocyte count (ALC) of ≥500 cells/μL on day 15. The majority (67%; n=16) of the patients had an ALC ≥500 cells/μL, and of these 10/16 are alive with a 5-year OS of 58.7% (13.2 SE). In contrast, 33% (n=8) of patients had an ALC <500 cells/μL on day 15 and only 2/8 are alive with a 5-year OS of 25% (15.3 SE). This difference was significant (P=0.007 using the log rank test). When comparing patients with metastatic disease, patients with an ALC-15 <500 cells/μL had a median survival of 13 months, whereas patients with an ALC-15 ≥500 cells/μL had a median survival of 29.5 months. All patients had an ALC before chemotherapy of >1000 cells/μL. The difference was significant (P value=0.001 using the log rank test). Univariate analysis of platelet counts, age, sex, and absolute neutrophil count showed no statistically significant association with OS. CONCLUSIONS: The data demonstrate that an ALC ≥500 cells/μL on day 15 of the first course of chemotherapy is an independent prognostic factor associated with superior OS in high-risk Ewing sarcoma.
KW - Absolute lymphocyte count
KW - Ewing sarcoma
KW - Prognostic factor
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U2 - 10.1097/MPH.0b013e31802d3e3e
DO - 10.1097/MPH.0b013e31802d3e3e
M3 - Article
C2 - 17230066
AN - SCOPUS:33846445664
SN - 1077-4114
VL - 29
SP - 48
EP - 52
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 1
ER -