TY - JOUR
T1 - Early-stage mycosis fungoides variants
T2 - Case-based review
AU - Cho-Vega, Jeong Hee
AU - Tschen, Jaime A.
AU - Duvic, Madeleine
AU - Vega, Francisco
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. The diagnosis of classic MF is based on a combination of clinical presentation, histopathology, and T-cell monoclonality detected by molecular studies. However, the diagnosis can be difficult in cases of early MF because of the subtle nature of histologic findings and, in cases of variants of MF, because of the unusual clinical and/or pathologic features. In this review, we presented the most frequent variants of MF at early stage including hypopigmented, folliculotropic, pagetoid reticulosis, unilesional, granulomatous, and ichthyosis forms. This case-based clinicopathologic review provides the notion that a comprehensive clinicopathologic correlation is of substantial importance to render the diagnosis of MF. In addition, we discuss the role of molecular studies, which are highly sensitive and recently more applicable to routinely processed skin biopsy specimens in the diagnosis of MF.
AB - Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. The diagnosis of classic MF is based on a combination of clinical presentation, histopathology, and T-cell monoclonality detected by molecular studies. However, the diagnosis can be difficult in cases of early MF because of the subtle nature of histologic findings and, in cases of variants of MF, because of the unusual clinical and/or pathologic features. In this review, we presented the most frequent variants of MF at early stage including hypopigmented, folliculotropic, pagetoid reticulosis, unilesional, granulomatous, and ichthyosis forms. This case-based clinicopathologic review provides the notion that a comprehensive clinicopathologic correlation is of substantial importance to render the diagnosis of MF. In addition, we discuss the role of molecular studies, which are highly sensitive and recently more applicable to routinely processed skin biopsy specimens in the diagnosis of MF.
KW - Early stage
KW - MF Variants
KW - Mycosis fungoides
KW - TCR gene rearrangment
KW - cutaneous T-cell lymphoma
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U2 - 10.1016/j.anndiagpath.2010.06.003
DO - 10.1016/j.anndiagpath.2010.06.003
M3 - Review article
C2 - 20850703
AN - SCOPUS:77956846413
SN - 1092-9134
VL - 14
SP - 369
EP - 385
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 5
ER -