Eastern asian expert panel opinion: Designing clinical trials of molecular targeted therapy for hepatocellular carcinoma

Winnie Yeo, Pei Jer Chen, Junji Furuse, Kwang Hyub Han, Chiun Hsu, Ho Yeong Lim, Hanlim Moon, Shukui Qin, Ee Min Yeoh, Sheng Long Ye

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    The largest burden of hepatocellular carcinoma (HCC) lies in Asia, secondary to hepatitis B virus (HBV) infection. Improved survival with sorafenib has fostered new research but many challenges remain in designing clinical trials. The disease, its management, and populations affected by it are heterogeneous worldwide and within Asia. An expert conference of Eastern Asian oncologists and hepatologists was convened to foster consensus in clinical trial design. The panel identified key areas that need to be addressed to facilitate clinical trials in Asia. Stratification by viral etiology is desirable within Asia and by region in global trials. Antiviral therapy should also be considered as a stratification factor and incorporated into HCC management in trials. The panel agreed that histological diagnosis is not required for trial entry and that Barcelona-Clinic Liver Cancer (BCLC) staging is acceptable for trials as long as portal hypertension can be better defined with standardized methodology. Consensus in treatment must be sought to allow multi-national trials and it must be recognized that first-line sorafenib is not largely feasible in Asia. Finally, Asian nations must be urged to participate in clinical trials, many of which are ongoing, to advance new treatment options in this challenging disease.

    Original languageEnglish (US)
    Article number620
    JournalBMC cancer
    Volume10
    DOIs
    StatePublished - Nov 10 2010

    ASJC Scopus subject areas

    • Genetics
    • Oncology
    • Cancer Research

    Fingerprint Dive into the research topics of 'Eastern asian expert panel opinion: Designing clinical trials of molecular targeted therapy for hepatocellular carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Yeo, W., Chen, P. J., Furuse, J., Han, K. H., Hsu, C., Lim, H. Y., Moon, H., Qin, S., Yeoh, E. M., & Ye, S. L. (2010). Eastern asian expert panel opinion: Designing clinical trials of molecular targeted therapy for hepatocellular carcinoma. BMC cancer, 10, [620]. https://doi.org/10.1186/1471-2407-10-620