Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor

Andrew M. Heitzer, Alexandra M. Villagran, Kimberly Raghubar, Austin L. Brown, Miranda L. Camet, M. Douglas Ris, Jenny H. Hanning, M. Fatih Okcu, Arnold C. Paulino, Murali Chintagumpala, Lisa S. Kahalley

Research output: Contribution to journalArticle

Abstract

Purpose: Survivors of pediatric embryonal brain tumors (BT) are at high risk for sensorineural hearing loss (SNHL) associated with neurocognitive decline. However, previous studies have not assessed the relationship between SNHL and adaptive functioning. We examined neurocognitive and adaptive functioning in patients with and without SNHL. Methods: Participants included 36 patients treated for an embryonal BT with craniospinal irradiation (CSI) and cisplatin chemotherapy who were assessed 6.7 years post-treatment on average. The impact of SNHL on neurocognitive performance and parent-rated adaptive functioning was assessed in univariate and multivariate analyses. Results: There were 17 cases with SNHL (mean age at evaluation = 14.4) and 19 cases with NH (mean age at evaluation = 13.8). After accounting for age at diagnosis and additional covariates in multivariable analyses, SNHL was associated with worse overall intellectual functioning (p = 0.027) and perceptual reasoning (p = 0.016) performance. There was no effect of SNHL on adaptive functioning in multivariable models. Age at diagnosis and sex were associated with performance on neurocognitive measures. Conclusions: SNHL in pediatric embryonal BT is associated with increased risk for neurocognitive deficits in conjunction with other demographic and treatment-related factors.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalJournal of neuro-oncology
Volume146
Issue number1
DOIs
StatePublished - Jan 1 2020

Fingerprint

Sensorineural Hearing Loss
Brain Neoplasms
Survivors
Pediatrics
Craniospinal Irradiation
Cisplatin
Multivariate Analysis
Demography
Drug Therapy
Therapeutics

Keywords

  • Adaptive
  • Cognitive
  • Embryonal brain tumor
  • Medulloblastoma
  • Pediatric
  • Sensorineural hearing loss

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Heitzer, A. M., Villagran, A. M., Raghubar, K., Brown, A. L., Camet, M. L., Ris, M. D., ... Kahalley, L. S. (2020). Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor. Journal of neuro-oncology, 146(1), 147-156. https://doi.org/10.1007/s11060-019-03356-z

Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor. / Heitzer, Andrew M.; Villagran, Alexandra M.; Raghubar, Kimberly; Brown, Austin L.; Camet, Miranda L.; Ris, M. Douglas; Hanning, Jenny H.; Okcu, M. Fatih; Paulino, Arnold C.; Chintagumpala, Murali; Kahalley, Lisa S.

In: Journal of neuro-oncology, Vol. 146, No. 1, 01.01.2020, p. 147-156.

Research output: Contribution to journalArticle

Heitzer, AM, Villagran, AM, Raghubar, K, Brown, AL, Camet, ML, Ris, MD, Hanning, JH, Okcu, MF, Paulino, AC, Chintagumpala, M & Kahalley, LS 2020, 'Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor', Journal of neuro-oncology, vol. 146, no. 1, pp. 147-156. https://doi.org/10.1007/s11060-019-03356-z
Heitzer, Andrew M. ; Villagran, Alexandra M. ; Raghubar, Kimberly ; Brown, Austin L. ; Camet, Miranda L. ; Ris, M. Douglas ; Hanning, Jenny H. ; Okcu, M. Fatih ; Paulino, Arnold C. ; Chintagumpala, Murali ; Kahalley, Lisa S. / Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor. In: Journal of neuro-oncology. 2020 ; Vol. 146, No. 1. pp. 147-156.
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AU - Camet, Miranda L.

AU - Ris, M. Douglas

AU - Hanning, Jenny H.

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