TY - JOUR
T1 - Effect of transcatheter intra-arterial therapies on tumor interstitial fluid pressure and its relation to drug penetration in a rabbit liver tumor model
AU - Liang, Bin
AU - Chen, Shaofeng
AU - Li, Lin
AU - Liu, Yiming
AU - Xiong, Fu
AU - Dong, Xiangjun
AU - Feng, Gansheng
AU - Gupta, Sanjay
AU - Zheng, Chuansheng
N1 - Funding Information:
This research was supported by National Natural Sciences Foundation of China Grants 81101134 and 81471765.
Publisher Copyright:
© 2015 SIR.
PY - 2015/12
Y1 - 2015/12
N2 - Purpose To determine the change in tumor interstitial fluid pressure (IFP) after transcatheter intra-arterial (IA) therapies and its relation to drug penetration in liver cancer. Materials and Methods VX2 tumors were grown in the livers of 16 rabbits. The rabbits were treated with intravenous injection of doxorubicin (group 1; n = 4), hepatic IA injection of doxorubicin (group 2; n = 4), hepatic IA injection of doxorubicin followed by embolization with polyvinyl alcohol particles (group 3; n = 4), or hepatic IA injection of doxorubicin mixed with Lipiodol followed by polyvinyl alcohol embolization (group 4; n = 4). Tumor IFP was measured with a Mikro-Tip pressure catheter before and 1 hour after treatment. Doxorubicin penetration was evaluated by immunofluorescence. Results Tumor IFP after treatment decreased by 5.0% ± 2.8, 3.9% ± 9.0, 27.1% ± 5.2, and 31.8% ± 7.4 in groups 1-4, respectively. The difference in IFP reduction between embolization-treated groups (groups 3 and 4) and nonembolized groups (groups 1 and 2) was significant (P <.001). Doxorubicin penetration distances were 20.3 μm ± 3.7, 45.7 μm ± 10.5, 69.5 μm ± 9.3, and 47.9 μm ± 6.4 in groups 1-4, respectively. IFP reduction was significantly correlated with doxorubicin penetration distance (r =.671, P =.004). Conclusions A greater reduction of tumor IFP was associated with embolization in a preclinical liver tumor model, and embolization may indirectly contribute to increased drug penetration.
AB - Purpose To determine the change in tumor interstitial fluid pressure (IFP) after transcatheter intra-arterial (IA) therapies and its relation to drug penetration in liver cancer. Materials and Methods VX2 tumors were grown in the livers of 16 rabbits. The rabbits were treated with intravenous injection of doxorubicin (group 1; n = 4), hepatic IA injection of doxorubicin (group 2; n = 4), hepatic IA injection of doxorubicin followed by embolization with polyvinyl alcohol particles (group 3; n = 4), or hepatic IA injection of doxorubicin mixed with Lipiodol followed by polyvinyl alcohol embolization (group 4; n = 4). Tumor IFP was measured with a Mikro-Tip pressure catheter before and 1 hour after treatment. Doxorubicin penetration was evaluated by immunofluorescence. Results Tumor IFP after treatment decreased by 5.0% ± 2.8, 3.9% ± 9.0, 27.1% ± 5.2, and 31.8% ± 7.4 in groups 1-4, respectively. The difference in IFP reduction between embolization-treated groups (groups 3 and 4) and nonembolized groups (groups 1 and 2) was significant (P <.001). Doxorubicin penetration distances were 20.3 μm ± 3.7, 45.7 μm ± 10.5, 69.5 μm ± 9.3, and 47.9 μm ± 6.4 in groups 1-4, respectively. IFP reduction was significantly correlated with doxorubicin penetration distance (r =.671, P =.004). Conclusions A greater reduction of tumor IFP was associated with embolization in a preclinical liver tumor model, and embolization may indirectly contribute to increased drug penetration.
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U2 - 10.1016/j.jvir.2015.05.031
DO - 10.1016/j.jvir.2015.05.031
M3 - Article
C2 - 26254117
AN - SCOPUS:84948113500
SN - 1051-0443
VL - 26
SP - 1879
EP - 1886
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 12
ER -