Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

Nam P. Nguyen; Misty Ceizyk; Paul Vos; Vincent Vinh-Hung; Rick Davis; Anand Desai; Dave Abraham; Shane P. Krafft; Siyoung Jang; Christopher J. Watchman; Lars Ewell; Russ Hamilton; Lexie Smith-Raymond

doi:10.1016/j.oraloncology.2010.01.010

Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

Nam P. Nguyen, Misty Ceizyk, Paul Vos, Vincent Vinh-Hung, Rick Davis, Anand Desai, Dave Abraham, Shane P. Krafft, Siyoung Jang, Christopher J. Watchman, Lars Ewell, Russ Hamilton, Lexie Smith-Raymond

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

Original language	English (US)
Pages (from-to)	283-286
Number of pages	4
Journal	Oral Oncology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.oraloncology.2010.01.010
State	Published - Apr 2010
Externally published	Yes

Keywords

Head and neck cancer
IGRT
Laryngeal sparing

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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10.1016/j.oraloncology.2010.01.010

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title = "Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer",

abstract = "We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.",

keywords = "Head and neck cancer, IGRT, Laryngeal sparing",

author = "Nguyen, {Nam P.} and Misty Ceizyk and Paul Vos and Vincent Vinh-Hung and Rick Davis and Anand Desai and Dave Abraham and Krafft, {Shane P.} and Siyoung Jang and Watchman, {Christopher J.} and Lars Ewell and Russ Hamilton and Lexie Smith-Raymond",

year = "2010",

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doi = "10.1016/j.oraloncology.2010.01.010",

language = "English (US)",

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journal = "Oral Oncology",

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AU - Nguyen, Nam P.

AU - Ceizyk, Misty

AU - Vos, Paul

AU - Vinh-Hung, Vincent

AU - Davis, Rick

AU - Desai, Anand

AU - Abraham, Dave

AU - Krafft, Shane P.

AU - Jang, Siyoung

AU - Watchman, Christopher J.

AU - Ewell, Lars

AU - Hamilton, Russ

AU - Smith-Raymond, Lexie

PY - 2010/4

Y1 - 2010/4

N2 - We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

AB - We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

KW - Head and neck cancer

KW - IGRT

KW - Laryngeal sparing

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ER -

Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

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