Effects of neocarzinostatin on mammalian nuclei Release of nucleosomes

M. Tien Kuo; T. S.A. Samy

doi:10.1016/0005-2787(78)90129-6

Effects of neocarzinostatin on mammalian nuclei Release of nucleosomes

M. Tien Kuo, T. S.A. Samy

Translational Molecular Pathology

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Abstract

When Chinese hamster cell nuclei (Line CHO) were reacted with neocarzinostatin and its DNA was analyzed on non-denaturing agarose gel electrophoresis, a series of bands with a multiplicity of 175 base pairs was obtained. A similar result was also obtained when the DNA samples were electrophoresed under denaturing gels. Our results suggest that the linker DNA between nucleosomes is the susceptible site to the drug and that neocarzinostatin can be used to study the chromatin structure.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	BBA Section Nucleic Acids And Protein Synthesis
Volume	518
Issue number	1
DOIs	https://doi.org/10.1016/0005-2787(78)90129-6
State	Published - Mar 29 1978

ASJC Scopus subject areas

General Medicine

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abstract = "When Chinese hamster cell nuclei (Line CHO) were reacted with neocarzinostatin and its DNA was analyzed on non-denaturing agarose gel electrophoresis, a series of bands with a multiplicity of 175 base pairs was obtained. A similar result was also obtained when the DNA samples were electrophoresed under denaturing gels. Our results suggest that the linker DNA between nucleosomes is the susceptible site to the drug and that neocarzinostatin can be used to study the chromatin structure.",

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AU - Samy, T. S.A.

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N2 - When Chinese hamster cell nuclei (Line CHO) were reacted with neocarzinostatin and its DNA was analyzed on non-denaturing agarose gel electrophoresis, a series of bands with a multiplicity of 175 base pairs was obtained. A similar result was also obtained when the DNA samples were electrophoresed under denaturing gels. Our results suggest that the linker DNA between nucleosomes is the susceptible site to the drug and that neocarzinostatin can be used to study the chromatin structure.

AB - When Chinese hamster cell nuclei (Line CHO) were reacted with neocarzinostatin and its DNA was analyzed on non-denaturing agarose gel electrophoresis, a series of bands with a multiplicity of 175 base pairs was obtained. A similar result was also obtained when the DNA samples were electrophoresed under denaturing gels. Our results suggest that the linker DNA between nucleosomes is the susceptible site to the drug and that neocarzinostatin can be used to study the chromatin structure.

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Effects of neocarzinostatin on mammalian nuclei Release of nucleosomes

Abstract

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