Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study

Carly S. Filgueira, Giacomo Bruno, Zachary W. Smith, Corrine Ying Xuan Chua, Andrea Ballerini, Marco Folci, April L. Gilbert, Priya Jain, Jagannadha K. Sastry, Pramod N. Nehete, Kathryn A. Shelton, Lori R. Hill, Areeba Ali, Keith A. Youker, Alessandro Grattoni

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

With nearly 40% of U.S. adults obese, and childhood and adolescent rates rising, obesity and associated comorbidities are serious public health concerns with massive societal costs. Often, lifestyle interventions do not offer sufficient weight loss to improve health, requiring surgery and medications as adjunct management strategies. Here, we present a 4-month case study in which the sustained, low-dose, and constant administration of the thyroid receptor β selective agonist GC-1 (sobetirome) from a novel nanochannel membrane implant was assessed in an obese, pre-diabetic rhesus macaque. Dramatic loss of white adipose tissue in the abdomen from 36 to 18% was observed via magnetic resonance imaging in conjunction with normalized serum insulin and glycemia, with no signs of cardiotoxicity shown. The non-human primate study highlights sustained low-dose delivery of GC-1 from our minimally invasive subcutaneous implant as a valuable approach to induce weight loss and manage obesity and comorbidities, including type 2 diabetes.

Original languageEnglish (US)
Article number49
JournalBiomedical Microdevices
Volume20
Issue number2
DOIs
StatePublished - Jun 1 2018

Keywords

  • GC-1
  • Non-human primate
  • Sobetirome
  • Sustained release
  • Thyroid hormone mimetics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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    Filgueira, C. S., Bruno, G., Smith, Z. W., Chua, C. Y. X., Ballerini, A., Folci, M., Gilbert, A. L., Jain, P., Sastry, J. K., Nehete, P. N., Shelton, K. A., Hill, L. R., Ali, A., Youker, K. A., & Grattoni, A. (2018). Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study. Biomedical Microdevices, 20(2), [49]. https://doi.org/10.1007/s10544-018-0296-2