Elderly patients with non-Hodgkin lymphoma who receive chemotherapy are at higher risk for osteoporosis and fractures

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Abstract

To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31% versus 19%, P < 0.001) and osteoporosis (10% versus 8%, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95% CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95% CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.

Original languageEnglish (US)
Pages (from-to)1514-1521
Number of pages8
JournalLeukemia and Lymphoma
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2007

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Non-Hodgkin's Lymphoma
Osteoporosis
Drug Therapy
Odds Ratio
Medicare
Demography
Neoplasms

Keywords

  • Fracture
  • Non-Hodgkin's lymphoma
  • Osteoporosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Elderly patients with non-Hodgkin lymphoma who receive chemotherapy are at higher risk for osteoporosis and fractures",
abstract = "To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31{\%} versus 19{\%}, P < 0.001) and osteoporosis (10{\%} versus 8{\%}, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95{\%} CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95{\%} CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.",
keywords = "Fracture, Non-Hodgkin's lymphoma, Osteoporosis",
author = "Cabanillas, {Maria E} and Huifang Lu and Shenying Fang and Du, {Xianglin L.}",
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T1 - Elderly patients with non-Hodgkin lymphoma who receive chemotherapy are at higher risk for osteoporosis and fractures

AU - Cabanillas, Maria E

AU - Lu, Huifang

AU - Fang, Shenying

AU - Du, Xianglin L.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31% versus 19%, P < 0.001) and osteoporosis (10% versus 8%, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95% CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95% CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.

AB - To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31% versus 19%, P < 0.001) and osteoporosis (10% versus 8%, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95% CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95% CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.

KW - Fracture

KW - Non-Hodgkin's lymphoma

KW - Osteoporosis

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