TY - JOUR
T1 - Elderly patients with non-Hodgkin lymphoma who receive chemotherapy are at higher risk for osteoporosis and fractures
AU - Cabanillas, Maria E.
AU - Lu, Huifang
AU - Fang, Shenying
AU - Du, Xianglin L.
N1 - Funding Information:
The SEER program, supported by the National Cancer Institute, consists of population-based tumor registries that collect standardized information on all cancers diagnosed within the specified geographic regions [19,20]. The metropolitan areas of San Francisco/Oakland, Detroit, Atlanta, and Seattle; Los Angeles County; the San Jose – Monterey area; and the states of Connecticut, Iowa, New Mexico, Utah, and Hawaii are included.
PY - 2007/8
Y1 - 2007/8
N2 - To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31% versus 19%, P < 0.001) and osteoporosis (10% versus 8%, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95% CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95% CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.
AB - To determine risk of osteoporosis and fractures associated with chemotherapy among elderly non-Hodgkin's lymphoma (NHL) patients, a cohort of 13 570 patients aged ≥65 years with incident NHL was identified from SEER-Medicare data with up to 11 years of follow-up. One year prior to the diagnosis, significantly fewer patients had fracture and osteoporosis claims in the chemotherapy group versus no chemotherapy group. However, after NHL diagnosis, patients who received chemotherapy had significantly higher rates of fracture (31% versus 19%, P < 0.001) and osteoporosis (10% versus 8%, P< 0.001), compared with those who did not. The risk of having fracture (odds ratio = 2.24, 95% CI = 2.04-2.45) and osteoporosis (odds ratio = 1.27, 95% CI = 1.12-1.45) was significantly higher in patients receiving chemotherapy compared with those who did not, after controlling for demographic and tumor factors. In conclusion, use of chemotherapy was significantly associated with increased risk of fracture and osteoporosis in elderly patients with NHL.
KW - Fracture
KW - Non-Hodgkin's lymphoma
KW - Osteoporosis
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U2 - 10.1080/10428190701471973
DO - 10.1080/10428190701471973
M3 - Article
C2 - 17701582
AN - SCOPUS:34547966607
SN - 1042-8194
VL - 48
SP - 1514
EP - 1521
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -