@inbook{e22e47bbe87a4d5db3cd9582cf7f7981,
title = "Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder",
abstract = "Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.",
keywords = "adrenocorticotropic hormone, corticotrophin-releasing factor, cortisol, posttraumatic stress disorder, stress, veterans",
author = "{de Kloet}, {C. S.} and E. Vermetten and E. Geuze and Lentjes, {E. G.W.M.} and Heijnen, {C. J.} and Stalla, {G. K.} and Westenberg, {H. G.M.}",
year = "2007",
doi = "10.1016/S0079-6123(07)67025-3",
language = "English (US)",
isbn = "0444531408",
series = "Progress in Brain Research",
pages = "287--291",
editor = "Ronlad Kloet and Melly Oitzl and Eric Vermetten",
booktitle = "Stress Hormones and Post Traumatic Stress Disorder Basic Studies and Clinical Perspectives",
}