Elevated ZNF703 protein expression is an independent unfavorable prognostic factor for survival of the patients with head and neck squamous cell carcinoma

Hang Yang, Wen Qi Jiang, Ye Cao, Yong An Sun, Jing Wei, Xin An, Ying Chun Zhang, Ming Song, Shu Sen Wang, Zhong Yu Yuan, Rou Jun Peng, Tan Huan Chen, Li Ren Li, Yan Xia Shi

Research output: Contribution to journalArticle

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Abstract

Aim: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear.The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods: Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected.The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results: The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05).Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073.2.493) in HNSCC patients. Conclusion: ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

Original languageEnglish (US)
Article number640263
JournalDisease markers
Volume2015
DOIs
StatePublished - Jan 1 2015

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Survival
Proteins
Tumors
Neoplasms
Genes
Tissue
Carcinoma, squamous cell of head and neck
Epithelial Cells
Atlases
Biomarkers
Solar System
Sun
Hazards
Multivariate Analysis
Immunohistochemistry
Genome
Carcinoma
Recurrence

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Elevated ZNF703 protein expression is an independent unfavorable prognostic factor for survival of the patients with head and neck squamous cell carcinoma. / Yang, Hang; Jiang, Wen Qi; Cao, Ye; Sun, Yong An; Wei, Jing; An, Xin; Zhang, Ying Chun; Song, Ming; Wang, Shu Sen; Yuan, Zhong Yu; Peng, Rou Jun; Chen, Tan Huan; Li, Li Ren; Shi, Yan Xia.

In: Disease markers, Vol. 2015, 640263, 01.01.2015.

Research output: Contribution to journalArticle

Yang, Hang ; Jiang, Wen Qi ; Cao, Ye ; Sun, Yong An ; Wei, Jing ; An, Xin ; Zhang, Ying Chun ; Song, Ming ; Wang, Shu Sen ; Yuan, Zhong Yu ; Peng, Rou Jun ; Chen, Tan Huan ; Li, Li Ren ; Shi, Yan Xia. / Elevated ZNF703 protein expression is an independent unfavorable prognostic factor for survival of the patients with head and neck squamous cell carcinoma. In: Disease markers. 2015 ; Vol. 2015.
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abstract = "Aim: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear.The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods: Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected.The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results: The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6{\%} versus 11.6{\%}, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05).Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95{\%} CI 1.073.2.493) in HNSCC patients. Conclusion: ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.",
author = "Hang Yang and Jiang, {Wen Qi} and Ye Cao and Sun, {Yong An} and Jing Wei and Xin An and Zhang, {Ying Chun} and Ming Song and Wang, {Shu Sen} and Yuan, {Zhong Yu} and Peng, {Rou Jun} and Chen, {Tan Huan} and Li, {Li Ren} and Shi, {Yan Xia}",
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AU - Yang, Hang

AU - Jiang, Wen Qi

AU - Cao, Ye

AU - Sun, Yong An

AU - Wei, Jing

AU - An, Xin

AU - Zhang, Ying Chun

AU - Song, Ming

AU - Wang, Shu Sen

AU - Yuan, Zhong Yu

AU - Peng, Rou Jun

AU - Chen, Tan Huan

AU - Li, Li Ren

AU - Shi, Yan Xia

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N2 - Aim: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear.The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods: Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected.The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results: The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05).Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073.2.493) in HNSCC patients. Conclusion: ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

AB - Aim: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear.The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods: Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected.The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results: The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05).Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073.2.493) in HNSCC patients. Conclusion: ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

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