TY - JOUR
T1 - Emerging roles for multimodal optical imaging in early cancer detection
T2 - A global challenge
AU - Bedard, Noah
AU - Pierce, Mark
AU - El-Naggar, Adel
AU - Anandasabapathy, S.
AU - Gillenwater, Ann
AU - Richards-Kortum, R.
PY - 2010/4
Y1 - 2010/4
N2 - Medical imaging technologies have become increasingly important in the clinical management of cancer, and now play key roles in cancer screening, diagnosis, staging, and monitoring response to treatment. Standard imaging modalities such as MRI, PET, and CT require significant financial resources and infrastructure, which limits access to these modalities to those patients in high-resource settings. In contrast, optical imaging strategies, with the potential for reduced cost and enhanced portability, are emerging as additional tools to facilitate the early detection and diagnosis of cancer. This article presents a vision for an expanding role for optical imaging in global cancer management, including screening, early detection at the point-of-care, biopsy guidance, and real-time histology. Multi-modal optical imaging - the combination of wide field and high resolution imaging - has the potential to aid in the detection and management of precancer and early cancer for traditionally underserved populations. Several recent widefield and high-resolution optical imaging technologies are described, along with requirements for implementing such devices into lower-resource settings.
AB - Medical imaging technologies have become increasingly important in the clinical management of cancer, and now play key roles in cancer screening, diagnosis, staging, and monitoring response to treatment. Standard imaging modalities such as MRI, PET, and CT require significant financial resources and infrastructure, which limits access to these modalities to those patients in high-resource settings. In contrast, optical imaging strategies, with the potential for reduced cost and enhanced portability, are emerging as additional tools to facilitate the early detection and diagnosis of cancer. This article presents a vision for an expanding role for optical imaging in global cancer management, including screening, early detection at the point-of-care, biopsy guidance, and real-time histology. Multi-modal optical imaging - the combination of wide field and high resolution imaging - has the potential to aid in the detection and management of precancer and early cancer for traditionally underserved populations. Several recent widefield and high-resolution optical imaging technologies are described, along with requirements for implementing such devices into lower-resource settings.
KW - Clinicaldiagnostics
KW - High-resolution imaging
KW - Microscopy
KW - Widefield imaging
UR - http://www.scopus.com/inward/record.url?scp=77952080602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952080602&partnerID=8YFLogxK
U2 - 10.1177/153303461000900210
DO - 10.1177/153303461000900210
M3 - Comment/debate
C2 - 20218743
AN - SCOPUS:77952080602
SN - 1533-0346
VL - 9
SP - 211
EP - 217
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 2
ER -