Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

Yunbao Pan; Huiling Yang; Francois X. Claret

doi:10.4161/cbt.27823

Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

Yunbao Pan
, Huiling Yang
, Francois X. Claret

Systems Biology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.

Original language	English (US)
Pages (from-to)	256-262
Number of pages	7
Journal	Cancer Biology and Therapy
Volume	15
Issue number	3
DOIs	https://doi.org/10.4161/cbt.27823
State	Published - Mar 2014

Keywords

DNA damage
Genomic instability
Jab1/CSN5
Therapeutic approach
Tumorigenesis

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.4161/cbt.27823

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@article{47ef7f946e7d4675a7d5bcb3270e97eb,

title = "Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer",

abstract = "Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.",

keywords = "DNA damage, Genomic instability, Jab1/CSN5, Therapeutic approach, Tumorigenesis",

author = "Yunbao Pan and Huiling Yang and Claret, \{Francois X.\}",

note = "Funding Information: Research in the laboratory is supported by funds from the National Natural Science Foundation of China (81372816) and the fellowship from the China Scholarship Council (2010638087) to YP; the National Natural Science Foundation of China (81071837) to H.Y.; the National Institutes of Health (1R01CA90853), the Cancer Prevention Research Institute of Texas (RP120451-01) and the University Cancer Foundation via the Sister Institution Network Fund at the University of Texas MD Anderson Cancer Center to F.X.C. We thank Elizabeth L Hess and Markeda L Wade in the Department of Scientific Publications at MD Anderson for editing the manuscript. This research is supported in part by the MD Anderson{\textquoteright}s Cancer Center Support Grant CA016672.",

year = "2014",

month = mar,

doi = "10.4161/cbt.27823",

language = "English (US)",

volume = "15",

pages = "256--262",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

AU - Pan, Yunbao

AU - Yang, Huiling

AU - Claret, Francois X.

N1 - Funding Information: Research in the laboratory is supported by funds from the National Natural Science Foundation of China (81372816) and the fellowship from the China Scholarship Council (2010638087) to YP; the National Natural Science Foundation of China (81071837) to H.Y.; the National Institutes of Health (1R01CA90853), the Cancer Prevention Research Institute of Texas (RP120451-01) and the University Cancer Foundation via the Sister Institution Network Fund at the University of Texas MD Anderson Cancer Center to F.X.C. We thank Elizabeth L Hess and Markeda L Wade in the Department of Scientific Publications at MD Anderson for editing the manuscript. This research is supported in part by the MD Anderson’s Cancer Center Support Grant CA016672.

PY - 2014/3

Y1 - 2014/3

N2 - Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.

AB - Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.

KW - DNA damage

KW - Genomic instability

KW - Jab1/CSN5

KW - Therapeutic approach

KW - Tumorigenesis

UR - https://www.scopus.com/pages/publications/84896520621

UR - https://www.scopus.com/pages/publications/84896520621#tab=citedBy

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DO - 10.4161/cbt.27823

M3 - Article

C2 - 24495954

AN - SCOPUS:84896520621

SN - 1538-4047

VL - 15

SP - 256

EP - 262

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 3

ER -

Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

Abstract

Keywords

ASJC Scopus subject areas

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