Abstract
The conventional treatment for cT3-T4 or node-positive clinically resectable rectal cancer is long course preoperative chemoradiation followed by surgery and postoperative adjuvant chemotherapy. Disadvantages of this approach include possible overtreatment of patients, 6 weeks of daily radiation treatment, and undetected metastatic disease. There are a number of emerging trends which are changing this approach to treatment. Selected topics included in this manuscript include the selective use of pelvic radiation, the role of radiation for a positive radial margin, the interval between radiation and surgery, non-operative management, new chemoradiation regimens, short vs. long course radiation, and the role of postoperative adjuvant chemotherapy.
Original language | English (US) |
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Pages (from-to) | 1343-1351 |
Number of pages | 9 |
Journal | Acta Oncologica |
Volume | 58 |
Issue number | 10 |
DOIs | |
State | Published - Oct 3 2019 |
ASJC Scopus subject areas
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging