EMT in cancer

Thomas Brabletz, Raghu Kalluri, M. Angela Nieto, Robert A. Weinberg

Research output: Contribution to journalReview articlepeer-review

1350 Scopus citations

Abstract

Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalNature Reviews Cancer
Volume18
Issue number2
DOIs
StatePublished - Jan 25 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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