TY - JOUR
T1 - EMT in cancer
AU - Brabletz, Thomas
AU - Kalluri, Raghu
AU - Nieto, M. Angela
AU - Weinberg, Robert A.
N1 - Publisher Copyright:
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2018/1/25
Y1 - 2018/1/25
N2 - Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.
AB - Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.
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U2 - 10.1038/nrc.2017.118
DO - 10.1038/nrc.2017.118
M3 - Review article
C2 - 29326430
AN - SCOPUS:85041115435
SN - 1474-175X
VL - 18
SP - 128
EP - 134
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 2
ER -