TY - JOUR
T1 - EMTome
T2 - a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures
AU - Vasaikar, Suhas V.
AU - Deshmukh, Abhijeet P.
AU - den Hollander, Petra
AU - Addanki, Sridevi
AU - Kuburich, Nick Allen
AU - Kudaravalli, Sriya
AU - Joseph, Robiya
AU - Chang, Jeffrey T.
AU - Soundararajan, Rama
AU - Mani, Sendurai A.
N1 - Funding Information:
Funding information This research was supported by CPRIT (RP160710/RP170172), NSF (15-597-1605817), NIH/NCI (R01CA200970, 2R01CA155243, and 5P30CA016672), and the Bowes Foundation, (to S.A.M. and NIH T32 (5T32CA186892) to N.A.K.
Publisher Copyright:
© 2020, The Author(s).
PY - 2021/1/5
Y1 - 2021/1/5
N2 - Background: The epithelial-mesenchymal transition (EMT) enables dissociation of tumour cells from the primary tumour mass, invasion through the extracellular matrix, intravasation into blood vessels and colonisation of distant organs. Cells that revert to the epithelial state via the mesenchymal-epithelial transition cause metastases, the primary cause of death in cancer patients. EMT also empowers cancer cells with stem-cell properties and induces resistance to chemotherapeutic drugs. Understanding the driving factors of EMT is critical for the development of effective therapeutic interventions. Methods: This manuscript describes the generation of a database containing EMT gene signatures derived from cell lines, patient-derived xenografts and patient studies across cancer types and multiomics data and the creation of a web-based portal to provide a comprehensive analysis resource. Results: EMTome incorporates (i) EMT gene signatures; (ii) EMT-related genes with multiomics features across different cancer types; (iii) interactomes of EMT-related genes (miRNAs, transcription factors, and proteins); (iv) immune profiles identified from The Cancer Genome Atlas (TCGA) cohorts by exploring transcriptomics, epigenomics, and proteomics, and drug sensitivity and (iv) clinical outcomes of cancer cohorts linked to EMT gene signatures. Conclusion: The web-based EMTome portal is a resource for primary and metastatic tumour research publicly available at www.emtome.org.
AB - Background: The epithelial-mesenchymal transition (EMT) enables dissociation of tumour cells from the primary tumour mass, invasion through the extracellular matrix, intravasation into blood vessels and colonisation of distant organs. Cells that revert to the epithelial state via the mesenchymal-epithelial transition cause metastases, the primary cause of death in cancer patients. EMT also empowers cancer cells with stem-cell properties and induces resistance to chemotherapeutic drugs. Understanding the driving factors of EMT is critical for the development of effective therapeutic interventions. Methods: This manuscript describes the generation of a database containing EMT gene signatures derived from cell lines, patient-derived xenografts and patient studies across cancer types and multiomics data and the creation of a web-based portal to provide a comprehensive analysis resource. Results: EMTome incorporates (i) EMT gene signatures; (ii) EMT-related genes with multiomics features across different cancer types; (iii) interactomes of EMT-related genes (miRNAs, transcription factors, and proteins); (iv) immune profiles identified from The Cancer Genome Atlas (TCGA) cohorts by exploring transcriptomics, epigenomics, and proteomics, and drug sensitivity and (iv) clinical outcomes of cancer cohorts linked to EMT gene signatures. Conclusion: The web-based EMTome portal is a resource for primary and metastatic tumour research publicly available at www.emtome.org.
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U2 - 10.1038/s41416-020-01178-9
DO - 10.1038/s41416-020-01178-9
M3 - Article
C2 - 33299129
AN - SCOPUS:85097311626
SN - 0007-0920
VL - 124
SP - 259
EP - 269
JO - British journal of cancer
JF - British journal of cancer
IS - 1
ER -