TY - JOUR
T1 - Endothelial dysfunction and vitamin D levels in kidney allograft recipients
AU - Altan, Mehmet
AU - Keven, Kenan
AU - Şengül, Şule
AU - Dinçer, Irem
AU - Ongun, Aydan
AU - Tolunay, Cansin
AU - Akar, Nejat
AU - Eǧin, Yonca
AU - Ertürk, Şehsuvar
PY - 2012
Y1 - 2012
N2 - There have been several studies demonstrating a relationship between vitamin D and cardiovascular disease. Vitamin D Deficiency/Insufficiency (D/I) is a common problem in chronic renal disease and also renal transplant recipients, however, there is a variation between the summer and winter periods. We investigated whether there is a relationship between vitamin D D/I and endothelial dysfunction in renal transplant recipients (RTR). We also evaluated vitamin D levels in summer and winter. Flowmediated dilatation (FMD), soluble endothelial protein receptor C (sEPRC) and soluble thrombomodulin (sTM) were chosen for markers of endothelial function. Firty-five patients were recruited to the study. Winter measurements were performed on March, summer measurements were performed in September. In the winter, methe an vitamin D level was 18.8±7.5, compared with 34.3±13.0 ng/ml in the summer period (p<0.0001). There were 38 (84%) and 20 (44%) patients in the winter and summer periods with vitamin D D/I, respectively. We did not find any significant association between vitamin D D/I and FMD, sTM or sEPCR in either period. While vitamin D D/I is a common finding during winter in RTR, it recovers in the summer. Moreover, vitamin D D/I seems not to be associated with endothelial dysfunction.
AB - There have been several studies demonstrating a relationship between vitamin D and cardiovascular disease. Vitamin D Deficiency/Insufficiency (D/I) is a common problem in chronic renal disease and also renal transplant recipients, however, there is a variation between the summer and winter periods. We investigated whether there is a relationship between vitamin D D/I and endothelial dysfunction in renal transplant recipients (RTR). We also evaluated vitamin D levels in summer and winter. Flowmediated dilatation (FMD), soluble endothelial protein receptor C (sEPRC) and soluble thrombomodulin (sTM) were chosen for markers of endothelial function. Firty-five patients were recruited to the study. Winter measurements were performed on March, summer measurements were performed in September. In the winter, methe an vitamin D level was 18.8±7.5, compared with 34.3±13.0 ng/ml in the summer period (p<0.0001). There were 38 (84%) and 20 (44%) patients in the winter and summer periods with vitamin D D/I, respectively. We did not find any significant association between vitamin D D/I and FMD, sTM or sEPCR in either period. While vitamin D D/I is a common finding during winter in RTR, it recovers in the summer. Moreover, vitamin D D/I seems not to be associated with endothelial dysfunction.
KW - Endothelial function
KW - Flow-mediated dilatation
KW - Kidney disease
KW - Renal transplantation
KW - Vitamin D
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U2 - 10.5262/tndt.2012.1001.09
DO - 10.5262/tndt.2012.1001.09
M3 - Article
AN - SCOPUS:84858853821
SN - 1300-7718
VL - 21
SP - 53
EP - 59
JO - Turkish Nephrology, Dialysis and Transplantation Journal
JF - Turkish Nephrology, Dialysis and Transplantation Journal
IS - 1
ER -