Abstract
In humans, exposure to endotoxins or pro-inflammatory cytokines induces a number of neuropsychological symptoms collectively referred to as 'flu-like syndrome'. The degree of overlap between flu-like syndrome and major depressive disorder is considerable and a close linkage between these has been predicted to arise due to hypersecretion of endogenous pro-inflammatory cytokines and activation of the hypothalamic pituitary adrenal axis. In animals, exposure to pro-inflammatory cytokines or endotoxins induces a 'sickness behavior' syndrome that is analogous to flu-like symptoms observed in human patients. The goal of the current paper is to review evidence implicating endotoxin- or cytokine-induced sickness behavior as an animal model of depression, with an emphasis on reduced consumption of highly palatable substances as a defining feature.
Original language | English (US) |
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Pages (from-to) | 761-770 |
Number of pages | 10 |
Journal | Neuroscience and Biobehavioral Reviews |
Volume | 29 |
Issue number | 4-5 |
DOIs | |
State | Published - 2005 |
Externally published | Yes |
Keywords
- Anhedonia
- Cytokines
- Depression
- Endotoxin
- Hedonia
- Lipopolysachharide
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience