Energy stress inhibits ferroptosis via AMPK

Hyemin Lee; Li Zhuang; Boyi Gan

doi:10.1080/23723556.2020.1761242

Energy stress inhibits ferroptosis via AMPK

Hyemin Lee, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.

Original language	English (US)
Article number	1761242
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2020.1761242
State	Published - Jul 3 2020

Keywords

AMP-activated protein kinase
Energy stress
acetyl-CoA carboxylase
ferroptosis
polyunsaturated fatty acid

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2020.1761242

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title = "Energy stress inhibits ferroptosis via AMPK",

abstract = "Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.",

keywords = "AMP-activated protein kinase, Energy stress, acetyl-CoA carboxylase, ferroptosis, polyunsaturated fatty acid",

author = "Hyemin Lee and Li Zhuang and Boyi Gan",

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AU - Zhuang, Li

AU - Gan, Boyi

PY - 2020/7/3

Y1 - 2020/7/3

N2 - Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.

AB - Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.

KW - AMP-activated protein kinase

KW - Energy stress

KW - acetyl-CoA carboxylase

KW - ferroptosis

KW - polyunsaturated fatty acid

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Energy stress inhibits ferroptosis via AMPK

Abstract

Keywords

ASJC Scopus subject areas

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