Enhancement of lung colony-forming efficiency by local thoracic irradiation: Interpretation of labeled cell studies

L. J. Peters, K. Mason, W. H. McBride, Y. Z. Patt

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The dynamics of 125IUdR-labeled tumor cell retention in the lungs have been compared with the efficiency of lung colony formation over a wide range of inoculum sizes in normal mice and in mice pretreated with 1000 rads local thoracic irradiation (LTI). These studies indicate that the increase in lung colony yield after LTI cannot be ascribed to improved intravascular trapping or interstitial lodgement of tumor cells. Hypotheses purporting that active specific or nonspecific host defenses might be impaired by LTI were reassessed but rejected in favor of the idea that radiation-induced alterations in the physiological microenvironment of the lungs improve an intrinsically poor survival capability of intravenously disseminated tumor cells.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalRadiology
Volume126
Issue number2
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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