Envisioning the molecular choreography of DNA base excision repair

Sudip S. Parikh; Clifford D. Mol; David J. Hosfield; John A. Tainer

doi:10.1016/S0959-440X(99)80006-2

Envisioning the molecular choreography of DNA base excision repair

Sudip S. Parikh
, Clifford D. Mol
, David J. Hosfield
, John A. Tainer

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Recent breakthroughs integrate individual DNA repair enzyme structures, biochemistry and biology to outline the structural cell biology of the DNA base excision repair pathways that are essential to genome integrity. Thus, we are starting to envision how the actions, movements, steps, partners and timing of DNA repair enzymes, which together define their molecular choreography, are elegantly controlled by both the nature of the DNA damage and the structural chemistry of the participating enzymes and the DNA double helix.

Original language	English (US)
Pages (from-to)	37-47
Number of pages	11
Journal	Current Opinion in Structural Biology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(99)80006-2
State	Published - Feb 1 1999
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(99)80006-2

Cite this

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title = "Envisioning the molecular choreography of DNA base excision repair",

abstract = "Recent breakthroughs integrate individual DNA repair enzyme structures, biochemistry and biology to outline the structural cell biology of the DNA base excision repair pathways that are essential to genome integrity. Thus, we are starting to envision how the actions, movements, steps, partners and timing of DNA repair enzymes, which together define their molecular choreography, are elegantly controlled by both the nature of the DNA damage and the structural chemistry of the participating enzymes and the DNA double helix.",

author = "Parikh, \{Sudip S.\} and Mol, \{Clifford D.\} and Hosfield, \{David J.\} and Tainer, \{John A.\}",

note = "Funding Information: We regret that space limitations prevented the discussion of many interesting related enzymes and earlier biochemical and structural results. We thank PK Cooper for useful insights regarding Figure 1 , and RP Cunningham, ED Getzoff, HE Krokan, RS Lloyd, TP Lo, KE Morgan, CD Putnam, B Shen, and G Slupphaug for helpful discussions, and DB Wigley for the DNA ligase coordinates. The authors{\textquoteright} work on DNA repair is supported by the National Institutes of Health (grant GM46312), a Special Fellowship from the Leukemia Society of America (CDM) and Graduate Research Fellowships from the National Science Foundation (SSP) and the Skaggs Institute for Research (DJH). ",

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AU - Hosfield, David J.

AU - Tainer, John A.

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AB - Recent breakthroughs integrate individual DNA repair enzyme structures, biochemistry and biology to outline the structural cell biology of the DNA base excision repair pathways that are essential to genome integrity. Thus, we are starting to envision how the actions, movements, steps, partners and timing of DNA repair enzymes, which together define their molecular choreography, are elegantly controlled by both the nature of the DNA damage and the structural chemistry of the participating enzymes and the DNA double helix.

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Envisioning the molecular choreography of DNA base excision repair

Abstract

ASJC Scopus subject areas

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