Epigenetic control of RNA polymerase I transcription in mammalian cells

Ingrid Grummt, Gernot Längst

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

rRNA synthesis is regulated by genetic and epigenetic mechanisms. Epigenetic states are metastable, changing in response to appropriate signals, thereby modulating transcription in vivo. The establishment, maintenance and reversal of epigenetic features are fundamental for the cell's ability to 'remember' past events, to adapt to environmental changes or developmental cues and to propagate this information to the progeny. As packaging into chromatin is critical for the stability and integrity of repetitive DNA, keeping a fraction of rRNA genes in a metastable heterochromatic conformation prevents aberrant exchanges between repeats, thus safeguarding nucleolar structure and rDNA stability. In this review, we will focus on the nature of the molecular signatures that characterize a given epigenetic state of rDNA in mammalian cells, including noncoding RNA, DNA methylation and histone modifications, and the mechanisms by which they are established and maintained. This article is part of a Special Issue entitled: Transcription by Odd Pols.

Original languageEnglish (US)
Pages (from-to)393-404
Number of pages12
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number3-4
DOIs
StatePublished - Mar 1 2013

Fingerprint

RNA Polymerase I
Transcription
Ribosomal DNA
Epigenomics
Cells
Untranslated RNA
Histones
Chromatin
Conformations
Packaging
Histone Code
Genes
Aptitude
DNA
Product Packaging
DNA Methylation
rRNA Genes
Cues
Maintenance

Keywords

  • DNA methylation
  • Epigenetics
  • Histone modifications
  • Noncoding RNA
  • Nucleosome positioning
  • RNA polymerase I

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Epigenetic control of RNA polymerase I transcription in mammalian cells. / Grummt, Ingrid; Längst, Gernot.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1829, No. 3-4, 01.03.2013, p. 393-404.

Research output: Contribution to journalReview article

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