Epigenetic mechanisms of induced pluripotency

Marta Gładych; Anastazja Andrzejewska; Urszula Oleksiewicz; Marcos R.H. Estécio

doi:10.5114/wo.2014.47135

Epigenetic mechanisms of induced pluripotency

Marta Gładych, Anastazja Andrzejewska, Urszula Oleksiewicz, Marcos R.H. Estécio

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

Original language	English (US)
Pages (from-to)	A30-A38
Journal	Wspolczesna Onkologia
Volume	1A
DOIs	https://doi.org/10.5114/wo.2014.47135
State	Published - 2015

Keywords

Chromatin modifications
DNA methylation
Epigenetics
Induced pluripotent stem cells

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

MD Anderson CCSG core facilities

Epigenomics Profiling Core Facility

Access to Document

10.5114/wo.2014.47135

Cite this

@article{74772f0297f0420291f499b6f610b3af,

title = "Epigenetic mechanisms of induced pluripotency",

abstract = "Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.",

keywords = "Chromatin modifications, DNA methylation, Epigenetics, Induced pluripotent stem cells",

author = "Marta G{\l}adych and Anastazja Andrzejewska and Urszula Oleksiewicz and Est{\'e}cio, {Marcos R.H.}",

year = "2015",

doi = "10.5114/wo.2014.47135",

language = "English (US)",

volume = "1A",

pages = "A30--A38",

journal = "Wspolczesna Onkologia",

issn = "1428-2526",

publisher = "Termedia Publishing House Ltd.",

}

TY - JOUR

T1 - Epigenetic mechanisms of induced pluripotency

AU - Gładych, Marta

AU - Andrzejewska, Anastazja

AU - Oleksiewicz, Urszula

AU - Estécio, Marcos R.H.

PY - 2015

Y1 - 2015

N2 - Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

AB - Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

KW - Chromatin modifications

KW - DNA methylation

KW - Epigenetics

KW - Induced pluripotent stem cells

UR - http://www.scopus.com/inward/record.url?scp=84981287939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981287939&partnerID=8YFLogxK

U2 - 10.5114/wo.2014.47135

DO - 10.5114/wo.2014.47135

M3 - Review article

C2 - 25691819

AN - SCOPUS:84981287939

SN - 1428-2526

VL - 1A

SP - A30-A38

JO - Wspolczesna Onkologia

JF - Wspolczesna Onkologia

ER -

Epigenetic mechanisms of induced pluripotency

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this