Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

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21 Scopus citations

Abstract

B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context.

Original languageEnglish (US)
Article number272
JournalFrontiers in Cell and Developmental Biology
Volume7
DOIs
StatePublished - Nov 7 2019

Keywords

  • B-cell lymphoma
  • BCL6
  • chromatin modifying genes
  • germinal center
  • histone acetylation
  • histone methylation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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