Abstract
B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context.
Original language | English (US) |
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Article number | 272 |
Journal | Frontiers in Cell and Developmental Biology |
Volume | 7 |
DOIs | |
State | Published - Nov 7 2019 |
Keywords
- B-cell lymphoma
- BCL6
- chromatin modifying genes
- germinal center
- histone acetylation
- histone methylation
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology