Epigenetic regulation of retinoic acid receptor β2 gene in the initiation of breast cancer

Jingyan Sun, Xu Xu, Juntian Liu, Hong Liu, Li Fu, Lin Gu

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    In order to investigate the methylation status of the retinoic acid receptor beta 2 gene (RAR-β2) in breast carcinoma in relation to gene expression and clinicopathological parameters of patients with breast cancer, expression of RAR-β2 gene and methylation status were analyzed in invasive carcinoma, atypical ductal hyperplasia, fibroadenoma specimens, and normal tissues. Our findings showed that RAR-β2 expression was lower in the breast cancer compared to normal tissue and fibroadenoma. The methylation rate of RAR-β2 in breast cancer and precancerous lesions of breast cancer were higher than that of normal tissues. Hypermethylation may be an initial step in breast carcinogenesis.

    Original languageEnglish (US)
    Pages (from-to)1311-1318
    Number of pages8
    JournalMedical Oncology
    Volume28
    Issue number4
    DOIs
    StatePublished - Dec 1 2011

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    Keywords

    • Breast neoplasms
    • DNA methylation
    • Methylation-specific polymerase chain reaction
    • Retinoic acid receptors

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Cancer Research

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