Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Lisa M. Becker, Joyce T. O'Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Becker et al. demonstrate that CAFs present with a pro-glycolytic phenotype, which helps to fuel the metabolism of breast cancer cells and promotes tumor growth. Chronic hypoxia induces the metabolic rewiring of normal fibroblasts toward a CAF-like, pro-glycolytic phenotype. These microenvironmental changes enabled the epigenetic alterations and expression of key glycolytic enzymes in CAFs.

Original languageEnglish (US)
Article number107701
JournalCell Reports
Volume31
Issue number9
DOIs
StatePublished - Jun 2 2020

Keywords

  • breast cancer
  • cancer-associated fibroblasts
  • epigenetic alterations
  • hypoxia
  • metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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