Becker et al. demonstrate that CAFs present with a pro-glycolytic phenotype, which helps to fuel the metabolism of breast cancer cells and promotes tumor growth. Chronic hypoxia induces the metabolic rewiring of normal fibroblasts toward a CAF-like, pro-glycolytic phenotype. These microenvironmental changes enabled the epigenetic alterations and expression of key glycolytic enzymes in CAFs.
- breast cancer
- cancer-associated fibroblasts
- epigenetic alterations
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)