@article{3ef995dd95dc496a83e5235188ba2fc3,
title = "Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer",
abstract = "Becker et al. demonstrate that CAFs present with a pro-glycolytic phenotype, which helps to fuel the metabolism of breast cancer cells and promotes tumor growth. Chronic hypoxia induces the metabolic rewiring of normal fibroblasts toward a CAF-like, pro-glycolytic phenotype. These microenvironmental changes enabled the epigenetic alterations and expression of key glycolytic enzymes in CAFs.",
keywords = "breast cancer, cancer-associated fibroblasts, epigenetic alterations, hypoxia, metabolism",
author = "Becker, {Lisa M.} and O'Connell, {Joyce T.} and Vo, {Annie P.} and Cain, {Margo P.} and Desiree Tampe and Lauren Bizarro and Hikaru Sugimoto and McGow, {Anna K.} and Asara, {John M.} and Sara Lovisa and McAndrews, {Kathleen M.} and Rafal Zielinski and Lorenzi, {Philip L.} and Michael Zeisberg and Sughra Raza and LeBleu, {Valerie S.} and Raghu Kalluri",
note = "Funding Information: The Kalluri laboratory was/is supported by the National Cancer Institute (NCI) ( CA125550 , CA155370 , and CA15192 ) and the Cancer Prevention and Research Institute of Texas (CPRIT). Additional support includes 5P01CA120964-05 and 5P30CA006516-46 from the NCI to J.M.A.; the Harvard Clinical and Translational Science Center training grant to A.P.V.; the Department of Defense Breast Cancer Research Predoctoral Traineeship Award ( W81XWH-09-1-0008 ) to J.T.O.; the NIH Research Training Grant in Gastroenterology ( 2T32DK007760-11 ) to V.S.L.; and the Rosalie Hite Fellowship at the University of Texas MD Anderson Cancer Center (MDACC) to L.M.B. The Metabolomics Core Facility at MDACC is supported by CPRIT grant RP130397 and NIH grants S10OD012304-01 , U01CA235510 , and P30CA016672 . We thank M. Esteller and J.F. Carmona Sanz for help with bisulfite sequencing, P. Phillips for help with immunohistochemistry, Y. Chen for advice on lymphatic immunolabeling, and F.L. Muller for helpful discussions regarding metabolic labeling studies. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jun,
day = "2",
doi = "10.1016/j.celrep.2020.107701",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}