Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Huihui Fan; Huda I. Atiya; Yeh Wang; Thomas R. Pisanic; Tza Huei Wang; Ie Ming Shih; Kelly K. Foy; Leonard Frisbie; Ronald J. Buckanovich; Alison A. Chomiak; Rochelle L. Tiedemann; Scott B. Rothbart; Chelsea Chandler; Hui Shen; Lan G. Coffman

doi:10.1016/j.celrep.2020.108473

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Huihui Fan
, Huda I. Atiya
, Yeh Wang
, Thomas R. Pisanic
, Tza Huei Wang
, Ie Ming Shih
, Kelly K. Foy
, Leonard Frisbie
, Ronald J. Buckanovich
, Alison A. Chomiak
, Rochelle L. Tiedemann
, Scott B. Rothbart
, Chelsea Chandler
, Hui Shen
, Lan G. Coffman

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

Original language	English (US)
Article number	108473
Journal	Cell Reports
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.108473
State	Published - Dec 8 2020
Externally published	Yes

Keywords

carcinoma-associated mesenchymal stem cells
epigenomic reprogramming
EZH2
mesenchymal-to-epithelial transition
metastasis
ovarian cancer
tumor microenvironment
WT1

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108473

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Fan, H., Atiya, H. I., Wang, Y., Pisanic, T. R., Wang, T. H., Shih, I. M., Foy, K. K., Frisbie, L., Buckanovich, R. J., Chomiak, A. A., Tiedemann, R. L., Rothbart, S. B., Chandler, C., Shen, H., & Coffman, L. G. (2020). Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis. Cell Reports, 33(10), Article 108473. https://doi.org/10.1016/j.celrep.2020.108473

Fan, H, Atiya, HI, Wang, Y, Pisanic, TR, Wang, TH, Shih, IM, Foy, KK, Frisbie, L, Buckanovich, RJ, Chomiak, AA, Tiedemann, RL, Rothbart, SB, Chandler, C, Shen, H & Coffman, LG 2020, 'Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis', Cell Reports, vol. 33, no. 10, 108473. https://doi.org/10.1016/j.celrep.2020.108473

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title = "Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis",

abstract = "Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.",

keywords = "carcinoma-associated mesenchymal stem cells, epigenomic reprogramming, EZH2, mesenchymal-to-epithelial transition, metastasis, ovarian cancer, tumor microenvironment, WT1",

author = "Huihui Fan and Atiya, \{Huda I.\} and Yeh Wang and Pisanic, \{Thomas R.\} and Wang, \{Tza Huei\} and Shih, \{Ie Ming\} and Foy, \{Kelly K.\} and Leonard Frisbie and Buckanovich, \{Ronald J.\} and Chomiak, \{Alison A.\} and Tiedemann, \{Rochelle L.\} and Rothbart, \{Scott B.\} and Chelsea Chandler and Hui Shen and Coffman, \{Lan G.\}",

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year = "2020",

month = dec,

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doi = "10.1016/j.celrep.2020.108473",

language = "English (US)",

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AU - Fan, Huihui

AU - Atiya, Huda I.

AU - Wang, Yeh

AU - Pisanic, Thomas R.

AU - Wang, Tza Huei

AU - Shih, Ie Ming

AU - Foy, Kelly K.

AU - Frisbie, Leonard

AU - Buckanovich, Ronald J.

AU - Chomiak, Alison A.

AU - Tiedemann, Rochelle L.

AU - Rothbart, Scott B.

AU - Chandler, Chelsea

AU - Shen, Hui

AU - Coffman, Lan G.

PY - 2020/12/8

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N2 - Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

AB - Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

KW - carcinoma-associated mesenchymal stem cells

KW - epigenomic reprogramming

KW - EZH2

KW - mesenchymal-to-epithelial transition

KW - metastasis

KW - ovarian cancer

KW - tumor microenvironment

KW - WT1

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AN - SCOPUS:85097460523

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Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Abstract

Keywords

ASJC Scopus subject areas

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