Epithelial stem cells: An epigenetic and Wnt-centric perspective

Bingnan Gu, Kazuhide Watanabe, Xing Dai

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Epithelial stem cells, such as those present in mammalian skin, intestine, or mammary gland, are tissue stem cells capable of both long-term self-renewal and multi-lineage differentiation. Here we review studies implicating epigenetic control mechanisms in mammalian epithelial stem cell development and homeostasis. We also provide an update of recent progresses in the involvement of canonical Wnt signaling and note an interesting link between the Wnt pathway and chromatin regulation in epithelial stem cells. We anticipate that epigenetic and epigenomic studies of these cells will increase exponentially in the near future.

Original languageEnglish (US)
Pages (from-to)1279-1287
Number of pages9
JournalJournal of cellular biochemistry
Volume110
Issue number6
DOIs
StatePublished - Aug 15 2010

Fingerprint

Stem cells
Epigenomics
Stem Cells
Epithelial Cells
Wnt Signaling Pathway
Human Mammary Glands
Chromatin
Intestines
Skin
Homeostasis
Tissue

Keywords

  • Chromatin
  • Epigenetics
  • Epithelial stem cell
  • Wnt signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Epithelial stem cells : An epigenetic and Wnt-centric perspective. / Gu, Bingnan; Watanabe, Kazuhide; Dai, Xing.

In: Journal of cellular biochemistry, Vol. 110, No. 6, 15.08.2010, p. 1279-1287.

Research output: Contribution to journalReview article

Gu, Bingnan ; Watanabe, Kazuhide ; Dai, Xing. / Epithelial stem cells : An epigenetic and Wnt-centric perspective. In: Journal of cellular biochemistry. 2010 ; Vol. 110, No. 6. pp. 1279-1287.
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