Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung

Lisandra Vila Ellis, Margo P. Cain, Vera Hutchison, Per Flodby, Edward D. Crandall, Zea Borok, Bin Zhou, Edwin J. Ostrin, Joshua D. Wythe, Jichao Chen

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Using imaging and single-cell RNA-seq, Vila Ellis et al. identify a lung endothelial cell (EC) population with a unique transcriptome, location, morphology, and function in lung development. These ECs are involved in alveolar morphogenesis independent of myofibroblasts.

Original languageEnglish (US)
Pages (from-to)617-630.e6
JournalDevelopmental cell
Volume52
Issue number5
DOIs
StatePublished - Mar 9 2020

Keywords

  • CAR4
  • VEGF
  • alveologenesis
  • angiogenesis
  • endothelial cell
  • lung alveolar type 1 cell
  • lung development
  • lung vasculature
  • single-cell RNA-seq
  • vascular biology

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology

MD Anderson CCSG core facilities

  • Flow Cytometry and Cellular Imaging Facility

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